open access

Vol 4, No 6 (2015)
Review articles (submitted)
Published online: 2016-02-22
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Optimizing a prandial insulin dosing in patients with type 1 diabetes

Karolina Jabłońska, Lilianna Majkowska
DOI: 10.5603/DK.2015.0032
·
Clinical Diabetology 2015;4(6):243-250.

open access

Vol 4, No 6 (2015)
Review articles (submitted)
Published online: 2016-02-22

Abstract

Intensive functional insulin therapy (FIT) relies on an algorithm for counting carbohydrate exchanges (CE) developed in the 1980s. With this method, patients with type 1 diabetes can tailor an insulin dose themselves depending on the amount of carbohydrates taken with food. However, it has been proven that proteins and fats affect the level of after-meal glycaemia and insulin secretion. This is caused by such factors as delayed gastric emptying and the involvement of proteins and fats in gluconeogenesis. To consider proteins and fats taken in meals, the concept of protein and fat exchanges (PFE) has been developed, which can be taken into account when calculating a prandial insulin dose. The aim of this paper is to explain various methods for intensive insulin therapy in patients with type 1 diabetes, treated either with continuous subcutaneous insulin infusion or with multiple dose injection.

Abstract

Intensive functional insulin therapy (FIT) relies on an algorithm for counting carbohydrate exchanges (CE) developed in the 1980s. With this method, patients with type 1 diabetes can tailor an insulin dose themselves depending on the amount of carbohydrates taken with food. However, it has been proven that proteins and fats affect the level of after-meal glycaemia and insulin secretion. This is caused by such factors as delayed gastric emptying and the involvement of proteins and fats in gluconeogenesis. To consider proteins and fats taken in meals, the concept of protein and fat exchanges (PFE) has been developed, which can be taken into account when calculating a prandial insulin dose. The aim of this paper is to explain various methods for intensive insulin therapy in patients with type 1 diabetes, treated either with continuous subcutaneous insulin infusion or with multiple dose injection.

Get Citation

Keywords

diabetes mellitus type 1, intensive functional therapy, carbohydrate exchanger, protein and fat exchanger

About this article
Title

Optimizing a prandial insulin dosing in patients with type 1 diabetes

Journal

Clinical Diabetology

Issue

Vol 4, No 6 (2015)

Pages

243-250

Published online

2016-02-22

DOI

10.5603/DK.2015.0032

Bibliographic record

Clinical Diabetology 2015;4(6):243-250.

Keywords

diabetes mellitus type 1
intensive functional therapy
carbohydrate exchanger
protein and fat exchanger

Authors

Karolina Jabłońska
Lilianna Majkowska

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