open access

Vol 4, No 5 (2015)
Review
Published online: 2015-12-18
Get Citation

Hyperglycaemia-induced oxidative stress in gestational diabetes mellitus (GDM)

Iga A. Turek, Lucyna A. Wozniak, Katarzyna Cypryk, Marzena Wojcik
DOI: 10.5603/DK.2015.0022
·
Diabetologia Kliniczna 2015;4(5):189-198.

open access

Vol 4, No 5 (2015)
Review
Published online: 2015-12-18

Abstract

An imbalance between production of reactive oxygen species (ROS) and their clearance by antioxidant defence mechanisms results in the development of oxidative stress. Biological consequences of this state involve oxidative damage of key cellular components such as nucleic acids, lipids, or proteins and, in turn, impairment of cell and tissue function. Evidence from clinical and experimental studies supports the notion that oxidative stress is one of pathologic factors associated with gestational diabetes mellitus (GDM), metabolic disorder defined as any degree of glucose intolerance with onset or first recognition during pregnancy. It has been established that high blood glucose concentrations in diabetic pregnancy induce oxidative stress by several mechanisms, including an enhanced ROS production in mitochondria, the polyol pathway and the hexosamine pathway, as well as protein kinase C (PKC) activation and an advanced glycation end-products (AGEs) formation, and changes in biomarkers of free radical-induced damage and antioxidant defences have been detected in maternal diabetes. Moreover, hyperglycaemia-induced oxidative stress is related with some congenital anomalies in diabetic pregnancy. The current article provides an overview how oxidative stress is related to GDM, with special emphasis on the involvement of the hyperglycaemia-induced mechanisms in ROS overproduction, followed by discussion of indicators of oxidative stress. In addition, the relationship between oxidative stress and congenital malformations in diabetic pregnancy is described.

Abstract

An imbalance between production of reactive oxygen species (ROS) and their clearance by antioxidant defence mechanisms results in the development of oxidative stress. Biological consequences of this state involve oxidative damage of key cellular components such as nucleic acids, lipids, or proteins and, in turn, impairment of cell and tissue function. Evidence from clinical and experimental studies supports the notion that oxidative stress is one of pathologic factors associated with gestational diabetes mellitus (GDM), metabolic disorder defined as any degree of glucose intolerance with onset or first recognition during pregnancy. It has been established that high blood glucose concentrations in diabetic pregnancy induce oxidative stress by several mechanisms, including an enhanced ROS production in mitochondria, the polyol pathway and the hexosamine pathway, as well as protein kinase C (PKC) activation and an advanced glycation end-products (AGEs) formation, and changes in biomarkers of free radical-induced damage and antioxidant defences have been detected in maternal diabetes. Moreover, hyperglycaemia-induced oxidative stress is related with some congenital anomalies in diabetic pregnancy. The current article provides an overview how oxidative stress is related to GDM, with special emphasis on the involvement of the hyperglycaemia-induced mechanisms in ROS overproduction, followed by discussion of indicators of oxidative stress. In addition, the relationship between oxidative stress and congenital malformations in diabetic pregnancy is described.

Get Citation

Keywords

biomarker; gestational diabetes mellitus (GDM); oxidative stress; reactive oxygen species (ROS)

About this article
Title

Hyperglycaemia-induced oxidative stress in gestational diabetes mellitus (GDM)

Journal

Clinical Diabetology

Issue

Vol 4, No 5 (2015)

Pages

189-198

Published online

2015-12-18

DOI

10.5603/DK.2015.0022

Bibliographic record

Diabetologia Kliniczna 2015;4(5):189-198.

Keywords

biomarker
gestational diabetes mellitus (GDM)
oxidative stress
reactive oxygen species (ROS)

Authors

Iga A. Turek
Lucyna A. Wozniak
Katarzyna Cypryk
Marzena Wojcik

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl