open access

Vol 4, No 4 (2015)
Original articles (submitted)
Published online: 2015-10-16
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Dietary carbohydrate content and glycaemic control in type 2 diabetes patients treated with pre-mixed human insulins

Tomasz Klupa, Bartlomiej Matejko, Przemyslaw Witek, Malgorzata Grzanka, Malgorzata Masierek, Pawel Gronowski, Magdalena Szopa, Maciej T. Malecki
DOI: 10.5603/DK.2015.0012
·
Diabetologia Kliniczna 2015;4(4):127-131.

open access

Vol 4, No 4 (2015)
Original articles (submitted)
Published online: 2015-10-16

Abstract

Introduction. The treatment with pre-mixed human insulins (PMHI) is globally one of the most popular models of insulin therapy. Achieving good glycaemic control on PMHI may, however, be difficult, mostly due to inconsistent calorie and carbohydrate intake. The aim of the study was to examine the impact of dietary modification on glucose levels in patients with type 2 diabetes mellitus (T2DM) treated with PMHI.

Materials and methods. In this prospective cross-over analysis we studied 8 T2DM PMHI treated individuals (mean HbA1c 8.4%). We exposed patients to 2 diets, both based on steady calorie/carbohydrate content: „A” — 50% calories from carbohydrates, 30% from fat, 20% from protein, „B”— 40% from carbohydrates, 30% from fat and 30% from protein. The study was performed in home settings, all the meals were delivered to the patients. Each patient was exposed to diet A for 9 days, than after 7 days of wash-out to 9 days of diet B. Glucose patterns were assessed with continuous glucose monitoring system (CGMS, iPro, Medtronic, USA).

Results. Switching from diet A to diet B resulted in a decrease in mean glucose levels (CGMS data) from 145 mg/dL to 133 mg/dL (p = 0.0001), SD reduction from 51 to 42 mg/dL (p = 0.0429), and a decrease in time spent above the target of 180 mg/dL from 18% to 11% (p = 0.0006).

Conclusions. The study demonstrates that consistent and repeatable carbohydrate (CH) and calorie intake with moderate restriction of CHs helps to improve glycaemic control in this group of patients.

Abstract

Introduction. The treatment with pre-mixed human insulins (PMHI) is globally one of the most popular models of insulin therapy. Achieving good glycaemic control on PMHI may, however, be difficult, mostly due to inconsistent calorie and carbohydrate intake. The aim of the study was to examine the impact of dietary modification on glucose levels in patients with type 2 diabetes mellitus (T2DM) treated with PMHI.

Materials and methods. In this prospective cross-over analysis we studied 8 T2DM PMHI treated individuals (mean HbA1c 8.4%). We exposed patients to 2 diets, both based on steady calorie/carbohydrate content: „A” — 50% calories from carbohydrates, 30% from fat, 20% from protein, „B”— 40% from carbohydrates, 30% from fat and 30% from protein. The study was performed in home settings, all the meals were delivered to the patients. Each patient was exposed to diet A for 9 days, than after 7 days of wash-out to 9 days of diet B. Glucose patterns were assessed with continuous glucose monitoring system (CGMS, iPro, Medtronic, USA).

Results. Switching from diet A to diet B resulted in a decrease in mean glucose levels (CGMS data) from 145 mg/dL to 133 mg/dL (p = 0.0001), SD reduction from 51 to 42 mg/dL (p = 0.0429), and a decrease in time spent above the target of 180 mg/dL from 18% to 11% (p = 0.0006).

Conclusions. The study demonstrates that consistent and repeatable carbohydrate (CH) and calorie intake with moderate restriction of CHs helps to improve glycaemic control in this group of patients.

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Keywords

type 2 diabetes, insulin, carbohydrates, glycaemic control, pre-mixed human insulins

About this article
Title

Dietary carbohydrate content and glycaemic control in type 2 diabetes patients treated with pre-mixed human insulins

Journal

Clinical Diabetology

Issue

Vol 4, No 4 (2015)

Pages

127-131

Published online

2015-10-16

DOI

10.5603/DK.2015.0012

Bibliographic record

Diabetologia Kliniczna 2015;4(4):127-131.

Keywords

type 2 diabetes
insulin
carbohydrates
glycaemic control
pre-mixed human insulins

Authors

Tomasz Klupa
Bartlomiej Matejko
Przemyslaw Witek
Malgorzata Grzanka
Malgorzata Masierek
Pawel Gronowski
Magdalena Szopa
Maciej T. Malecki

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