open access

Vol 4, No 3 (2015)
Review
Published online: 2015-07-16
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Glucocortycosteroids and disturbances of glucose metabolism

Dorota Pisarczyk-Wiza, Dorota Zozulińska-Ziółkiewicz
DOI: 10.5603/DK.2015.0010
·
Diabetologia Kliniczna 2015;4(3):110-116.

open access

Vol 4, No 3 (2015)
Review
Published online: 2015-07-16

Abstract

Glucocorticosteroids (GS) are a group of steroid hormones that regulate human physiological reactions of a wide spectrum of the necessities of life, such as growth, reproduction, immune and inflammatory reactions. Synthetic corticosteroids are commonly used drugs in inflammatory, autoimmune and lymphoproliferative diseases. However, steroids therapy is associated with the occurrence of many side effects, including metabolic disturbances. One of them is poststeroid diabetes. Several mechanisms are responsible for diabetogenic effect of GS, such as antagonistic action against insulin, increase of insulin resistance at the level of the liver, skeletal muscle and adipose tissue, impaired secretory capacity of the beta cells, effects on alpha cells leading to increase glucagon secretion, decreased the incretin phenomenon and gathering visceral fat. Disturbances in glucose metabolism induced by the action of GS are characterized by normal or slightly elevated fasting glucose and markedly postprandial glucose increase, especially in the afternoon and evening. Therapeutic efforts should therefore be directed at combating these particular disorders.

Abstract

Glucocorticosteroids (GS) are a group of steroid hormones that regulate human physiological reactions of a wide spectrum of the necessities of life, such as growth, reproduction, immune and inflammatory reactions. Synthetic corticosteroids are commonly used drugs in inflammatory, autoimmune and lymphoproliferative diseases. However, steroids therapy is associated with the occurrence of many side effects, including metabolic disturbances. One of them is poststeroid diabetes. Several mechanisms are responsible for diabetogenic effect of GS, such as antagonistic action against insulin, increase of insulin resistance at the level of the liver, skeletal muscle and adipose tissue, impaired secretory capacity of the beta cells, effects on alpha cells leading to increase glucagon secretion, decreased the incretin phenomenon and gathering visceral fat. Disturbances in glucose metabolism induced by the action of GS are characterized by normal or slightly elevated fasting glucose and markedly postprandial glucose increase, especially in the afternoon and evening. Therapeutic efforts should therefore be directed at combating these particular disorders.

Get Citation

Keywords

glucocorticosteroids, glucose metabolism, diabetes

About this article
Title

Glucocortycosteroids and disturbances of glucose metabolism

Journal

Clinical Diabetology

Issue

Vol 4, No 3 (2015)

Pages

110-116

Published online

2015-07-16

DOI

10.5603/DK.2015.0010

Bibliographic record

Diabetologia Kliniczna 2015;4(3):110-116.

Keywords

glucocorticosteroids
glucose metabolism
diabetes

Authors

Dorota Pisarczyk-Wiza
Dorota Zozulińska-Ziółkiewicz

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