Vol 1, No 1 (2000): Practical Diabetology
Other materials agreed with the Editors
Published online: 2000-09-26
Frequency of Liver Disease in Type 2 Diabetic Patients Treated With Oral Antidiabetic Agents
Diabetologia Praktyczna 2000;1(1):75-82.
Abstract
OBJECTIVE. We evaluated liver disease in conventionally
treated type 2 diabetic patients to provide
a reference against which reports of liver disease
related to novel oral antidiabetic treatments could
be compared.
RESEARCH DESIGN AND METHODS. In this follow-up study, patients with type 2 diabetes who were treated with oral antidiabetic agents were identified from the U.K.-based General Practice Research Database and were followed to determine whether they developed liver disease. The specific types and etiologies of liver disorders were determined. Incidence rates were calculated based on the accumulated exposure time to oral antidiabetic agents.
RESULTS. Among 44,406 type 2 diabetic patients, 605 had a computer diagnosis of liver disease with an incidence rate of 53.2/10,000 person-years (95% CI 49.2–57.6). Of the 605 subjects, 186 had nonsymp
RESEARCH DESIGN AND METHODS. In this follow-up study, patients with type 2 diabetes who were treated with oral antidiabetic agents were identified from the U.K.-based General Practice Research Database and were followed to determine whether they developed liver disease. The specific types and etiologies of liver disorders were determined. Incidence rates were calculated based on the accumulated exposure time to oral antidiabetic agents.
RESULTS. Among 44,406 type 2 diabetic patients, 605 had a computer diagnosis of liver disease with an incidence rate of 53.2/10,000 person-years (95% CI 49.2–57.6). Of the 605 subjects, 186 had nonsymp