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Vol 2, No 3 (2001): Practical Diabetology
Original articles (submitted)
Published online: 2001-06-15
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The effect of intensive insulin therapy on the body mass index and lipids in patients with type 1 diabetes mellitus - retrospective analysis

Elżbieta Kozek, Anna Citkowska, Katarzyna Fross, Aleksandra Górska, Agnieszka Marcinkowska, Jacek Sieradzki
Diabetologia Praktyczna 2001;2(3):203-208.

open access

Vol 2, No 3 (2001): Practical Diabetology
Original articles (submitted)
Published online: 2001-06-15

Abstract

OBJECTIVE. The purpose of the study was a retrospective analysis of intensive insulin therapy in patients with type 1 diabetes mellitus with special consideration of its effects on the body mass index (BMI), lipid profile, diabetes control and daily insulin requirement.
RESEARCH DESING AND METHODS. Case histories of type 1 diabetics hospitalised in the Department of Metabolic Diseases between 1995 and 1999 were analysed. Each hospitalised patient received intensive insulin therapy (IIT) and attended a course on diabetes education.
RESULTS. In 72 patients (37 women and 35 men) with a mean age of 31,85 ± 11,88 years the results of control examinations were evaluated at 1 to 4 years after IIT. BMI was found to increase significantly (22,84 ± 3,05 vs. 24,07 ± 3,29 kg/m2, p < 0,001). Total cholesterol was significantly higher (4,75 ± ± 1,10 vs 5,07 ± 1,21 mmol/l, p < 0,05), similar to HDL cholesterol (1,44 ± 0,49 vs. 1,63 ± 0,38 mmol/l, p <0,05). No significant differences were seen in triglycerides, LDL cholesterol and atherogenic index. At 1–4 years after IIT diabetes control was significantly improved (HbA1c: 8,50 ± 2,37 vs. 7,40 ± 1,69%, p < 0,01). There was a significant positive correlation between BMI and LDL cholesterol (r = 0,41, p < 0,005) and between HbA1c and triglycerides (r = 0,53, p < 0,05).
CONCLUSIONS. The retrospective analysis shows that IIT in patients with type 1 diabetes mellitus improved glycaemia control. Body weight gain expressed as BMI was an unfavourable effect. The increased BMI was not associated with the atherogenic lipid profile based upon increased HDL cholesterol. The favourable changes in the lipid profile despite the increased BMI may result from improved diabetes control due to IIT.

Abstract

OBJECTIVE. The purpose of the study was a retrospective analysis of intensive insulin therapy in patients with type 1 diabetes mellitus with special consideration of its effects on the body mass index (BMI), lipid profile, diabetes control and daily insulin requirement.
RESEARCH DESING AND METHODS. Case histories of type 1 diabetics hospitalised in the Department of Metabolic Diseases between 1995 and 1999 were analysed. Each hospitalised patient received intensive insulin therapy (IIT) and attended a course on diabetes education.
RESULTS. In 72 patients (37 women and 35 men) with a mean age of 31,85 ± 11,88 years the results of control examinations were evaluated at 1 to 4 years after IIT. BMI was found to increase significantly (22,84 ± 3,05 vs. 24,07 ± 3,29 kg/m2, p < 0,001). Total cholesterol was significantly higher (4,75 ± ± 1,10 vs 5,07 ± 1,21 mmol/l, p < 0,05), similar to HDL cholesterol (1,44 ± 0,49 vs. 1,63 ± 0,38 mmol/l, p <0,05). No significant differences were seen in triglycerides, LDL cholesterol and atherogenic index. At 1–4 years after IIT diabetes control was significantly improved (HbA1c: 8,50 ± 2,37 vs. 7,40 ± 1,69%, p < 0,01). There was a significant positive correlation between BMI and LDL cholesterol (r = 0,41, p < 0,005) and between HbA1c and triglycerides (r = 0,53, p < 0,05).
CONCLUSIONS. The retrospective analysis shows that IIT in patients with type 1 diabetes mellitus improved glycaemia control. Body weight gain expressed as BMI was an unfavourable effect. The increased BMI was not associated with the atherogenic lipid profile based upon increased HDL cholesterol. The favourable changes in the lipid profile despite the increased BMI may result from improved diabetes control due to IIT.
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Keywords

type 1 diabetes; intensive insulin therapy; body mass index; lipids

About this article
Title

The effect of intensive insulin therapy on the body mass index and lipids in patients with type 1 diabetes mellitus - retrospective analysis

Journal

Clinical Diabetology

Issue

Vol 2, No 3 (2001): Practical Diabetology

Pages

203-208

Published online

2001-06-15

Bibliographic record

Diabetologia Praktyczna 2001;2(3):203-208.

Keywords

type 1 diabetes
intensive insulin therapy
body mass index
lipids

Authors

Elżbieta Kozek
Anna Citkowska
Katarzyna Fross
Aleksandra Górska
Agnieszka Marcinkowska
Jacek Sieradzki

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