Vol 2, No 3 (2001): Practical Diabetology
Other materials agreed with the Editors
Published online: 2001-06-15
Glucose metabolism in pregnancy at high altitude
Diabetologia Praktyczna 2001;2(3):219-447.
Abstract
OBJECTIVE. To assess insulin sensitivity and b-cell function
associated with lower maternal fasting plasma glucose
levels at high altitude compared with sea level.
RESEARCH DESIGN AND METHODS. We studied 215 pregnant women at 842 weeks of gestation in Peru. The women were recruited from Cerro de Pasco, which is situated 4,370 m (14,340 feet) above sea level, and Lima, which is at sea level. We also examined 53 nonpregnant control subjects (22 in Cerro de Pasco and 31 in Lima). Fasting plasma glucose, insulin, C-peptide, and proinsulin concentrations were measured in samples obtained from the antecubital vein between 8:00 A.M. and 10:00 A.M. after an overnight period of fasting for 1014 h. Insulin resistance and b-cell function were calculated using homeostasis model assessment.
RESULTS. Fasting C-peptide levels and b-cell function were similar, fasting concentrations of insulin and proinsulin were lower, and insulin sensitivity was higher at high altitude compared with sea level.
CONCLUSIONS. Maternal fasting plasma glucose that is lower at high altitude than at sea level in the presence of similar insulin secretion is associated with higher peripheral insulin sensitivity. This may partly explain the lower birth weights at high altitudes.
RESEARCH DESIGN AND METHODS. We studied 215 pregnant women at 842 weeks of gestation in Peru. The women were recruited from Cerro de Pasco, which is situated 4,370 m (14,340 feet) above sea level, and Lima, which is at sea level. We also examined 53 nonpregnant control subjects (22 in Cerro de Pasco and 31 in Lima). Fasting plasma glucose, insulin, C-peptide, and proinsulin concentrations were measured in samples obtained from the antecubital vein between 8:00 A.M. and 10:00 A.M. after an overnight period of fasting for 1014 h. Insulin resistance and b-cell function were calculated using homeostasis model assessment.
RESULTS. Fasting C-peptide levels and b-cell function were similar, fasting concentrations of insulin and proinsulin were lower, and insulin sensitivity was higher at high altitude compared with sea level.
CONCLUSIONS. Maternal fasting plasma glucose that is lower at high altitude than at sea level in the presence of similar insulin secretion is associated with higher peripheral insulin sensitivity. This may partly explain the lower birth weights at high altitudes.
Keywords: pregnacyglycemiainsulin sensitivityliving at high altitudebirth weight