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Limited value of the homeostasis model assessment to predict insulin resistance in older men with impaired glucose tolerance
open access
Abstract
MATERIAL AND METHODS. We assessed the validity of HOMA-IR as an index of IR by comparing it to glucose infusion rates (GIRs) measured by a glucose clamp (600 pmol x m-2 x min-1) in 45 obese men (61 ± 8 years of age, mean ± SD) with normal glucose tolerance (NGT) (n = 21) or impaired glucose tolerance (IGT) (n = 24). We also evaluated relationships between body composition, exercise capacity, and IR.
RESULTS. Subjects with NGT had lower BMI (28 ± 3 vs. 31 ± 3 kg/m2), waist circumference (97 ± 9 vs. 105 ± ± 9 cm), waist-to-hip ratio (WHR) (0.93 ± 0.06 vs. 0.97 ± 0.05), and percent body fat (25 ± 6 vs. 30 ± ± 6) than subjects with IGT. Subjects with NGT also had lower areas above basal during the 2-h oral glucose tolerance test for glucose (274 ± 95 vs. 419 ± ± 124 mmol x min/l) and insulin (38.142 ± 18.206 vs. 58.383 ± 34.408 pmol x min/l) and lower HOMA-IR values (2.2 ± 0.8 vs. 4.2 ± 2.6) than subjects with IGT. GIR (mmol x kg-1 FFM x min-1) was higher in subjects with NGT than in subjects with IGT (53 ± 11 vs. 43 ± 14). HOMA-IR correlated with GIR in subjects with NGT (r = –0.59), but not in subjects with IGT (r = –0.13). GIR correlated with VO2max in subjects with NGT (r = 0.58) and IGT (r = 0.42), but with WHR only in subjects with NGT (r = –0.53). HOMA-IR correlated with VO2max (r = –0,57) and waist circumference (r = 0.54) in subjects with NGT, but with percent body fat in subjects witch IGT (r = 0.54).
CONCLUSIONS. These findings indicate that HOMA- -IR should not be used as an index of IR in older individuals who may be at risk for IGT, and suggest that lifestyle changes that increase VO2max and decrease body fat may reduce IR in older people.
Abstract
MATERIAL AND METHODS. We assessed the validity of HOMA-IR as an index of IR by comparing it to glucose infusion rates (GIRs) measured by a glucose clamp (600 pmol x m-2 x min-1) in 45 obese men (61 ± 8 years of age, mean ± SD) with normal glucose tolerance (NGT) (n = 21) or impaired glucose tolerance (IGT) (n = 24). We also evaluated relationships between body composition, exercise capacity, and IR.
RESULTS. Subjects with NGT had lower BMI (28 ± 3 vs. 31 ± 3 kg/m2), waist circumference (97 ± 9 vs. 105 ± ± 9 cm), waist-to-hip ratio (WHR) (0.93 ± 0.06 vs. 0.97 ± 0.05), and percent body fat (25 ± 6 vs. 30 ± ± 6) than subjects with IGT. Subjects with NGT also had lower areas above basal during the 2-h oral glucose tolerance test for glucose (274 ± 95 vs. 419 ± ± 124 mmol x min/l) and insulin (38.142 ± 18.206 vs. 58.383 ± 34.408 pmol x min/l) and lower HOMA-IR values (2.2 ± 0.8 vs. 4.2 ± 2.6) than subjects with IGT. GIR (mmol x kg-1 FFM x min-1) was higher in subjects with NGT than in subjects with IGT (53 ± 11 vs. 43 ± 14). HOMA-IR correlated with GIR in subjects with NGT (r = –0.59), but not in subjects with IGT (r = –0.13). GIR correlated with VO2max in subjects with NGT (r = 0.58) and IGT (r = 0.42), but with WHR only in subjects with NGT (r = –0.53). HOMA-IR correlated with VO2max (r = –0,57) and waist circumference (r = 0.54) in subjects with NGT, but with percent body fat in subjects witch IGT (r = 0.54).
CONCLUSIONS. These findings indicate that HOMA- -IR should not be used as an index of IR in older individuals who may be at risk for IGT, and suggest that lifestyle changes that increase VO2max and decrease body fat may reduce IR in older people.
Keywords
homeostasis model assessment; impaired glucose tolerance; insulin resistance


Title
Limited value of the homeostasis model assessment to predict insulin resistance in older men with impaired glucose tolerance
Journal
Issue
Vol 2, No 4 (2001): Practical Diabetology
Article type
Other materials agreed with the Editors
Pages
299-306
Published online
2001-11-19
Page views
673
Article views/downloads
3585
Bibliographic record
Diabetologia Praktyczna 2001;2(4):299-306.
Keywords
homeostasis model assessment
impaired glucose tolerance
insulin resistance
Authors
Cynthia M. Ferrara
Adrew P. Goldberg