open access

Vol 2, No 4 (2001): Practical Diabetology
Original articles (translated)
Published online: 2001-11-19
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Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects

Kjeld Hermansen, Mette Sondergaard, Lars Hoie, Marius Carstensen, Brigitte Brock
Diabetologia Praktyczna 2001;2(4):291-298.

open access

Vol 2, No 4 (2001): Practical Diabetology
Original articles (translated)
Published online: 2001-11-19

Abstract

INTRODUCTION. Consumption of soy protein has recently been shown to improve the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in type 2 diabetic subjects.
MATERIAL AND METHODS. Twenty type 2 diabetic subjects participated in a crossover trial. They were randomized to double-blind supplementation for 6 weeks with Abalon (soy protein [50 g/day] with high levels of isoflavones [minimum 165 mg/day] and cotyledon fiber [20 g/day]) or placebo (casein [50 g/day] and cellulose [20 g/day]), separated by a 3-week wash-out period.
RESULTS. The results are expressed as means ± SD. The percentage mean treatment difference between Abalon and placebo demonstrated significantly lower mean values after Abalon for LDL cholesterol (10 ± 15%; P < 0.05), LDL/HDL ratio (12 ± 18%; P < <0.05), apolipoprotein (apo) B100 (30 ± 38%; P < 0.01), triglycerides (22 ± 10%; P < 0.05), and homocysteine (14 ± 21%; P < 0.01), whereas the total cholesterol value tended to be less significant but still lower (8 ± 15%; P < 0.08). No change occurred in HDL cholesterol, apo B100/apo A 1 ratio, plasminogen activator inhibitor 1, factor VIIc, von Willebrand factor, fibrinogen, lipoprotein(a), glucose, HbA1c, or 24-h blood pressure.
CONCLUSIONS. These results indicate beneficial effects of dietary supplementation with Abalon on cardiovascular risk markers in type 2 diabetic subjects. This improvement is seen even in individuals with near-normal lipid values.

Abstract

INTRODUCTION. Consumption of soy protein has recently been shown to improve the blood lipid levels in nondiabetic subjects. The purpose of this study was to evaluate if a dietary supplement of soy protein, isoflavones, and cotyledon fiber (Abalon) affects cardiovascular risk markers, blood glucose, and insulin levels in type 2 diabetic subjects.
MATERIAL AND METHODS. Twenty type 2 diabetic subjects participated in a crossover trial. They were randomized to double-blind supplementation for 6 weeks with Abalon (soy protein [50 g/day] with high levels of isoflavones [minimum 165 mg/day] and cotyledon fiber [20 g/day]) or placebo (casein [50 g/day] and cellulose [20 g/day]), separated by a 3-week wash-out period.
RESULTS. The results are expressed as means ± SD. The percentage mean treatment difference between Abalon and placebo demonstrated significantly lower mean values after Abalon for LDL cholesterol (10 ± 15%; P < 0.05), LDL/HDL ratio (12 ± 18%; P < <0.05), apolipoprotein (apo) B100 (30 ± 38%; P < 0.01), triglycerides (22 ± 10%; P < 0.05), and homocysteine (14 ± 21%; P < 0.01), whereas the total cholesterol value tended to be less significant but still lower (8 ± 15%; P < 0.08). No change occurred in HDL cholesterol, apo B100/apo A 1 ratio, plasminogen activator inhibitor 1, factor VIIc, von Willebrand factor, fibrinogen, lipoprotein(a), glucose, HbA1c, or 24-h blood pressure.
CONCLUSIONS. These results indicate beneficial effects of dietary supplementation with Abalon on cardiovascular risk markers in type 2 diabetic subjects. This improvement is seen even in individuals with near-normal lipid values.
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Keywords

soy–based dietary supplement; type 2 diabetes; cardiovascular risk markers

About this article
Title

Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects

Journal

Clinical Diabetology

Issue

Vol 2, No 4 (2001): Practical Diabetology

Pages

291-298

Published online

2001-11-19

Bibliographic record

Diabetologia Praktyczna 2001;2(4):291-298.

Keywords

soy–based dietary supplement
type 2 diabetes
cardiovascular risk markers

Authors

Kjeld Hermansen
Mette Sondergaard
Lars Hoie
Marius Carstensen
Brigitte Brock

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