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Vol 2, No 4 (2001): Practical Diabetology
Original articles (translated)
Published online: 2001-11-19
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The association of heart-rate variability with cardiovascular risk factors and coronary artery calcification. A study in type 1 diabetic patients and the general population

Helen M. Colhoun, Darrel P. Francis, Michael B. Rubens, S. Richard Underwood, John H. Fuller
Diabetologia Praktyczna 2001;2(4):281-298.

open access

Vol 2, No 4 (2001): Practical Diabetology
Original articles (translated)
Published online: 2001-11-19

Abstract

INTRODUCTION. To examine the association of heart- rate variability with cardiovascular risk factors and coronary calcification in type 1 diabetic and nondiabetic subjects without a history of cardiovascular disease. Reduced heart-rate variability is associated with increased risk of coronary events. Whether it is associated with coronary atherosclerosis is unknown.
MATERIAL AND METHODS. Power spectral analysis was used to define heart-rate variability in a cross- -sectional study of 160 type 1 diabetic patients and 163 randomly selected nondiabetic adults from the general population aged 30–55 years. Coronary artery calcification was measured using electron beam–computed tomography.
RESULTS. Reduced heart-rate variability was associated with similar risk factors in the diabetic and nondiabetic subjects, namely higher HbA1c, triglycerides, systolic blood pressure, BMI, and albumin excretion rate. Reduced heart-rate variability was significantly associated with coronary artery calcification in all subjects (odds ratio per tertile lower total power = 1.5; P = 0.01). This association was not independent of blood pressure or BMI (odds ratio on adjustment = 1.3; P = 0.1).
CONCLUSIONS. Reduced heart-rate variability clusters with other cardiovascular disease risk factors, especially those that are more common in the insulin resistance syndrome, and is associated with increased coronary calcification in asymptomatic young adults. Whether reduced heart-rate variability leads to other risk factor disturbances or mediates the effects of other risk factors on atherosclerosis deserves further study.

Abstract

INTRODUCTION. To examine the association of heart- rate variability with cardiovascular risk factors and coronary calcification in type 1 diabetic and nondiabetic subjects without a history of cardiovascular disease. Reduced heart-rate variability is associated with increased risk of coronary events. Whether it is associated with coronary atherosclerosis is unknown.
MATERIAL AND METHODS. Power spectral analysis was used to define heart-rate variability in a cross- -sectional study of 160 type 1 diabetic patients and 163 randomly selected nondiabetic adults from the general population aged 30–55 years. Coronary artery calcification was measured using electron beam–computed tomography.
RESULTS. Reduced heart-rate variability was associated with similar risk factors in the diabetic and nondiabetic subjects, namely higher HbA1c, triglycerides, systolic blood pressure, BMI, and albumin excretion rate. Reduced heart-rate variability was significantly associated with coronary artery calcification in all subjects (odds ratio per tertile lower total power = 1.5; P = 0.01). This association was not independent of blood pressure or BMI (odds ratio on adjustment = 1.3; P = 0.1).
CONCLUSIONS. Reduced heart-rate variability clusters with other cardiovascular disease risk factors, especially those that are more common in the insulin resistance syndrome, and is associated with increased coronary calcification in asymptomatic young adults. Whether reduced heart-rate variability leads to other risk factor disturbances or mediates the effects of other risk factors on atherosclerosis deserves further study.
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Keywords

heart-rate variability; atheromatosis coronary calcification; cardiovascular risk factors

About this article
Title

The association of heart-rate variability with cardiovascular risk factors and coronary artery calcification. A study in type 1 diabetic patients and the general population

Journal

Clinical Diabetology

Issue

Vol 2, No 4 (2001): Practical Diabetology

Pages

281-298

Published online

2001-11-19

Bibliographic record

Diabetologia Praktyczna 2001;2(4):281-298.

Keywords

heart-rate variability
atheromatosis coronary calcification
cardiovascular risk factors

Authors

Helen M. Colhoun
Darrel P. Francis
Michael B. Rubens
S. Richard Underwood
John H. Fuller

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