Vol 3, No 2 (2002): Practical Diabetology
Other materials agreed with the Editors
Published online: 2002-05-13
Association of Chlamydia pneumoniae infection with diabetic nephropathy
Diabetologia Praktyczna 2002;3(2):91-94.
Abstract
We evaluated the association of Chlamydia pneumoniae
(CP) infection with progression of diabetic
nephropathy. Type 2 diabetic patients (60) were divided
into two groups, those with incipient nephropathy
and those with advanced nephropathy, based
on the severity of diffuse glomerular lesions using
Gellman’s criteria. Type 2 (34) diabetic patients without
nephropathy (normoalbuminuria) and 59
nondiabetics served as control groups. Serum IgG-
-antibody against CP was measured using ELISA.
CP antibody was detected in 45.8% of nondiabetic
controls, in 47.1% of diabetic patients without nephropathy,
in 52.6% of diabetic patients with incipient
nephropathy, and 78% of diabetic patients
with advanced nephropathy. There was 4.22-fold increase
in the risk of advanced nephropathy associated
with the presence of CP antibody. Our findings
indicate an association between chronic CP infection
and advanced diabetic nephropathy.
Keywords: Chlamydia pneumoniaediabetic nephropathyrenal biopsy