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Vol 3, No 4 (2002): Practical Diabetology
Original articles (translated)
Published online: 2002-09-25
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Small bowel motility affects glucose absorption in a healthy man

Matthijs P. Schwartz, Melvin Samsom, Willem Renooij, Leo W. van Steenderen, Marc A. Benninga, Erwin-Jan M. van Geenen, Margot A. van Herwaarden, Martin B.M. de Smet, André J.P.M. Smout
Diabetologia Praktyczna 2002;3(4):273-282.

open access

Vol 3, No 4 (2002): Practical Diabetology
Original articles (translated)
Published online: 2002-09-25

Abstract

INTRODUCTION. To investigate the relationship between duodenojejunal motor activity and glucose absorption and to evaluate the effect of modification of duodenojejunal motility on glucose absorption by using the prokinetic drug cisapride.
MATERIAL AND METHODS. We examined seven healthy males, mean age 22 years, who were treated with cisapride 10 mg t.i.d. and placebo during 3 days in a randomized order, with a 2-week time interval. Duodenojejunal manometry was performed after each treatment on the morning of day 3, using an 18-lumen catheter. A liquid nutrient (3 kcal/min) was administered intraduodenally for 30 min, followed by a bolus of the glucose analog 3-O-methylglucose (3-OMG). Plasma 3-OMG concentrations were measured to assess absorption kinetics.
RESULTS. The area under the 3-OMG concentration curve in the first 30 min after infusion was related to the number of antegrade propagated pressure waves (r = 0.49, P < 0.05), but not to the peak concentration, time to peak, and absorption fraction. The mean amplitude of pressure waves was higher during cisapride than placebo (P < 0.05), but the reoccurrence of interdigestive motility, numbers of pressure waves, and propagated pressure waves, as well as 3-OMG absorption characteristics, were not significantly different between the two treatments. During both treatments > 60% of antegrade propagated pressure waves were propagated over a very short distance (1.5 cm).
CONCLUSIONS. Glucose absorption in the human small intestine is related to short-traveling propagated intestinal contractile activity. Cisapride increases the amplitude of pressure waves, but does not affect the organization of pressure waves or the absorption of 3-OMG.

Abstract

INTRODUCTION. To investigate the relationship between duodenojejunal motor activity and glucose absorption and to evaluate the effect of modification of duodenojejunal motility on glucose absorption by using the prokinetic drug cisapride.
MATERIAL AND METHODS. We examined seven healthy males, mean age 22 years, who were treated with cisapride 10 mg t.i.d. and placebo during 3 days in a randomized order, with a 2-week time interval. Duodenojejunal manometry was performed after each treatment on the morning of day 3, using an 18-lumen catheter. A liquid nutrient (3 kcal/min) was administered intraduodenally for 30 min, followed by a bolus of the glucose analog 3-O-methylglucose (3-OMG). Plasma 3-OMG concentrations were measured to assess absorption kinetics.
RESULTS. The area under the 3-OMG concentration curve in the first 30 min after infusion was related to the number of antegrade propagated pressure waves (r = 0.49, P < 0.05), but not to the peak concentration, time to peak, and absorption fraction. The mean amplitude of pressure waves was higher during cisapride than placebo (P < 0.05), but the reoccurrence of interdigestive motility, numbers of pressure waves, and propagated pressure waves, as well as 3-OMG absorption characteristics, were not significantly different between the two treatments. During both treatments > 60% of antegrade propagated pressure waves were propagated over a very short distance (1.5 cm).
CONCLUSIONS. Glucose absorption in the human small intestine is related to short-traveling propagated intestinal contractile activity. Cisapride increases the amplitude of pressure waves, but does not affect the organization of pressure waves or the absorption of 3-OMG.
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Keywords

small bowel motility; glucose absorption; cisapride

About this article
Title

Small bowel motility affects glucose absorption in a healthy man

Journal

Clinical Diabetology

Issue

Vol 3, No 4 (2002): Practical Diabetology

Pages

273-282

Published online

2002-09-25

Bibliographic record

Diabetologia Praktyczna 2002;3(4):273-282.

Keywords

small bowel motility
glucose absorption
cisapride

Authors

Matthijs P. Schwartz
Melvin Samsom
Willem Renooij
Leo W. van Steenderen
Marc A. Benninga
Erwin-Jan M. van Geenen
Margot A. van Herwaarden
Martin B.M. de Smet
André J.P.M. Smout

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