Thiazolidinediones and insulin resistance

Abstract

Thiazolidenediones - insulin sensitisers - are a relatively new class of antidiabetic agents which enhance sensitivity to insulin in the liver, adipose tissue and muscles, resulting in improved insulin-mediated glucose disposal. They works through activation of the peroxisome proliferator - activated receptor g, a nuclear receptor that expression of several genes involved in metabolism. This receptor controls adipocyte differentiation, lipid storage and insulin sensitization. Thiazolidinediones have effects on cell proliferation and tumorigenesis. Gliatazones have influence on lipids parameters, increase lean body mass and decrease total body fat. They reduce expression of leptin and tumor necrosis factor.