open access

Vol 3, No 4 (2002): Practical Diabetology
Review articles (submitted)
Published online: 2002-09-25
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Thiazolidinediones and insulin resistance

Anna Modzelewska, Małgorzata Szelachowska, Anna Zonenberg, Ida Kinalska
Diabetologia Praktyczna 2002;3(4):219-226.

open access

Vol 3, No 4 (2002): Practical Diabetology
Review articles (submitted)
Published online: 2002-09-25

Abstract

Thiazolidenediones - insulin sensitisers - are a relatively new class of antidiabetic agents which enhance sensitivity to insulin in the liver, adipose tissue and muscles, resulting in improved insulin-mediated glucose disposal. They works through activation of the peroxisome proliferator - activated receptor g, a nuclear receptor that expression of several genes involved in metabolism. This receptor controls adipocyte differentiation, lipid storage and insulin sensitization. Thiazolidinediones have effects on cell proliferation and tumorigenesis. Gliatazones have influence on lipids parameters, increase lean body mass and decrease total body fat. They reduce expression of leptin and tumor necrosis factor.

Abstract

Thiazolidenediones - insulin sensitisers - are a relatively new class of antidiabetic agents which enhance sensitivity to insulin in the liver, adipose tissue and muscles, resulting in improved insulin-mediated glucose disposal. They works through activation of the peroxisome proliferator - activated receptor g, a nuclear receptor that expression of several genes involved in metabolism. This receptor controls adipocyte differentiation, lipid storage and insulin sensitization. Thiazolidinediones have effects on cell proliferation and tumorigenesis. Gliatazones have influence on lipids parameters, increase lean body mass and decrease total body fat. They reduce expression of leptin and tumor necrosis factor.
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Keywords

tiazolidinediony; rosiglitazon; troglitazon; insulinooporność; cukrzyca

About this article
Title

Thiazolidinediones and insulin resistance

Journal

Clinical Diabetology

Issue

Vol 3, No 4 (2002): Practical Diabetology

Pages

219-226

Published online

2002-09-25

Bibliographic record

Diabetologia Praktyczna 2002;3(4):219-226.

Keywords

tiazolidinediony
rosiglitazon
troglitazon
insulinooporność
cukrzyca

Authors

Anna Modzelewska
Małgorzata Szelachowska
Anna Zonenberg
Ida Kinalska

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