Vol 4, No 2 (2003): Practical Diabetology
Research paper
Published online: 2003-04-28
Application of gliclazide MR in uncontrolled diabetes type 2 — the treatment phase results of DINAMIC 2 study (V)
Diabetologia Praktyczna 2003;4(2):133-136.
Abstract
Tight glycemic control is universally acknowledged
as a therapeutic priority in multifactorial management
in type 2 diabetes [1, 2]. Achieving control
to recommended targets, typically defined as
Ł 7% or even Ł 6,5% glycated hemoglobin [1, 2],
improves microvascular [3, 4] and possibly macrovascular
[4] outcomes, but represents a considerable
clinical challenge and carries resource implications.
DINAMIC 2 study sampled populations of type
2 diabetic patients attending in primary care settings,
in order to generate data about of glycemia [5]. Following
this survey phase of the study other data,
patients identified as having inadequate control
were included into a 6 month trial of the efficacy
and acceptability of once-daily sulfonylurea preparation,
gliclazide modified release (Diamicron MR),
alone or in combination with other oral antidiabetic
agents.