Recent progress in diabetic trombophilia prophylaxis and treatment

Abstract

Diabetes predisposes to the imbalance between coagulation and fibrinolysis, resulting in the prothrombotic state. This predisposition is due to altered platelet function, increased activity of some coagulation factors — especially fibrinogen and von Willebrandt factor — as well as to impaired fibrinolysis. In the present study we analysed the most common disturbances, and the methods of prophylaxis and treatment of thrombotic complications, with regard to the role of antiplatelet drugs and thrombin inhibitors.