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Vol 4, No 3 (2003): Practical Diabetology
Original articles (submitted)
Published online: 2003-05-22
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Platelet Na+/H+ exchanger activity in patients with coronary heart disease confirmed by selective arteriography and the disturbances of carbohydrate metabolism

Beata Telejko, Marian Tomasiak, Halina Stelmach, Hanna Bachórzewska-Gajewska, Konrad Nowak, Wacław Kochman, Ida Kinalska
Diabetologia Praktyczna 2003;4(3):185-192.

open access

Vol 4, No 3 (2003): Practical Diabetology
Original articles (submitted)
Published online: 2003-05-22

Abstract

INTRODUCTION. Enhanced activity of Na+/H+ exchangers (NHE, sodium/proton exchanger) has been previously described in patients with arterial hypertension, poorly controlled type 1 and type 2 diabetes and nephropathy. There were also clinical trials with NHE1 inhibitors in patients with acute coronary syndromes. The aim of our study was the estimation of platelet Na+/H+ exchanger activity and selected risk factors in patients referred for coronary angiography, dependent on the disturbances of carbohydrate metabolism and atherosclerotic lesions.
MATERIAL AND METHODS. Platelet Na+/H+ exchanger activity was measured in platelet rich plasma, using an optical swelling assay, in 55 consecutive patients (7 with impaired glucose tolerance [IGT] and 14 with type 2 diabetes) with positive exercise test (mean age 57.3 ± 6.6 years) and in 32 healthy subjects (mean age 48.4 ± 9.0 years).
RESULTS. Na+/H+ exchanger activity was markedly increased in patients with coronary heart disease in comparison to the controls (4.36 ± 0.90 × 10-3 × s-1 vs 3.18 ± 0.55 × 10-3 × s-1, p = 0.000001). However, there was no significant differences between subjects with 1-, 2- and 3-vessel disease, nor with and without arterial hypertension (4.48 ± 0.92 × 10-3 × s-1 vs 4.34 ± 0.88 × 10-3 × s-1), as well as between patients with normal glucose tolerance, IGT and type 2 diabetes, however the mean values in each group were significantly higher than in the controls. Na+/H+ exchanger activity correlated with BMI (r = 0.30, p = 0.047).
CONCLUSIONS. Our study suggests enhanced activity of platelet Na+/H+ exchanger in patients with coronary heart disease, but the problem needs further investigations.

Abstract

INTRODUCTION. Enhanced activity of Na+/H+ exchangers (NHE, sodium/proton exchanger) has been previously described in patients with arterial hypertension, poorly controlled type 1 and type 2 diabetes and nephropathy. There were also clinical trials with NHE1 inhibitors in patients with acute coronary syndromes. The aim of our study was the estimation of platelet Na+/H+ exchanger activity and selected risk factors in patients referred for coronary angiography, dependent on the disturbances of carbohydrate metabolism and atherosclerotic lesions.
MATERIAL AND METHODS. Platelet Na+/H+ exchanger activity was measured in platelet rich plasma, using an optical swelling assay, in 55 consecutive patients (7 with impaired glucose tolerance [IGT] and 14 with type 2 diabetes) with positive exercise test (mean age 57.3 ± 6.6 years) and in 32 healthy subjects (mean age 48.4 ± 9.0 years).
RESULTS. Na+/H+ exchanger activity was markedly increased in patients with coronary heart disease in comparison to the controls (4.36 ± 0.90 × 10-3 × s-1 vs 3.18 ± 0.55 × 10-3 × s-1, p = 0.000001). However, there was no significant differences between subjects with 1-, 2- and 3-vessel disease, nor with and without arterial hypertension (4.48 ± 0.92 × 10-3 × s-1 vs 4.34 ± 0.88 × 10-3 × s-1), as well as between patients with normal glucose tolerance, IGT and type 2 diabetes, however the mean values in each group were significantly higher than in the controls. Na+/H+ exchanger activity correlated with BMI (r = 0.30, p = 0.047).
CONCLUSIONS. Our study suggests enhanced activity of platelet Na+/H+ exchanger in patients with coronary heart disease, but the problem needs further investigations.
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Keywords

platelet Na+/H+ exchanger; coronary heart disease; type 2 diabetes

About this article
Title

Platelet Na+/H+ exchanger activity in patients with coronary heart disease confirmed by selective arteriography and the disturbances of carbohydrate metabolism

Journal

Clinical Diabetology

Issue

Vol 4, No 3 (2003): Practical Diabetology

Pages

185-192

Published online

2003-05-22

Bibliographic record

Diabetologia Praktyczna 2003;4(3):185-192.

Keywords

platelet Na+/H+ exchanger
coronary heart disease
type 2 diabetes

Authors

Beata Telejko
Marian Tomasiak
Halina Stelmach
Hanna Bachórzewska-Gajewska
Konrad Nowak
Wacław Kochman
Ida Kinalska

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