open access

Vol 4, No 4 (2003): Practical Diabetology
Original articles (submitted)
Published online: 2003-09-18
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Fibrinogen as a coronary risk factor in patients with type 2 diabetes mellitus

Elżbieta Kozek, Tomasz Klupa, Przemysław Witek, Maciej Małecki, Jacek Sieradzki
Diabetologia Praktyczna 2003;4(4):265-272.

open access

Vol 4, No 4 (2003): Practical Diabetology
Original articles (submitted)
Published online: 2003-09-18

Abstract

INTRODUCTION. Epidemiological and clinical studies have demonstrated that increased plasma fibrinogen concentration is an independent cardiovascular risk factor. Patients with type 2 diabetes mellitus more frequently and earlier than others develop atherosclerotic lesions and their clinical manifestations, including coronary artery disease; mortality due to atherosclerotic complications is also increased. Elevated fibrinogen with subsequent hypercoagulability and subclinical inflammatory state may account for increased atherosclerotic risk in these patients. Aim of the study. Evaluation of changes fibrinogen in patients with type 2 diabetes mellitus and nondiabetics in relation to coronary artery disease, effect of metabolic normalisation, sex, age, smoking, BMI and WHR on fibrinogen and assessment of independent coronary risk factors in the two study groups.
MATERIAL AND METHODS. The study was conducted in 114 patients, including 61 with type 2 diabetes mellitus, aged 58.6 ± 7.8 years, 26 males and 35 females, and 53 patients aged 53.2 ± 8.6 years, 20 males and 33 females, without carbohydrate abnormalities. Clinical and biochemical parameters were analysed. Plasma fibrinogen was measured using the modified Clauss method (Fibrintimer, Behringwerke).
RESULTS. Fibrinogen concentration in patients with diabetes mellitus and coronary artery disease was significantly higher than in diabetics without coronary artery disease (3.05 ± 0.75 vs. 2.45 ± 0.85 g/ P < 0.01) and in diabetics irrespective of the presence of coronary artery disease (2.61 ± 0.66 and 2.30 ± 0.56 g/l; P < 0.01). Multiple regression analysis revealed that smoking (P < 0.001) and age (P < 0.05) independently modify fibrinogen concentration. Multiple regression analysis also revealed that independent risk factors associated with coronary artery disease in diabetics are microalbuminuria (P < 0.01) and fibrinogen (P < 0.05), whereas nondiabetics it is total cholesterol (P < 0.05).
CONCLUSIONS. In this study type 2 diabetics with coronary artery disease had significantly higher fibrinogen concentration. Fibrinogen concentration was independently modified by smoking and age. Independent risk factors associated with coronary artery disease in diabetics were microalbuminuria and fibrinogen, whereas in nondiabetics it was total cholesterol.

Abstract

INTRODUCTION. Epidemiological and clinical studies have demonstrated that increased plasma fibrinogen concentration is an independent cardiovascular risk factor. Patients with type 2 diabetes mellitus more frequently and earlier than others develop atherosclerotic lesions and their clinical manifestations, including coronary artery disease; mortality due to atherosclerotic complications is also increased. Elevated fibrinogen with subsequent hypercoagulability and subclinical inflammatory state may account for increased atherosclerotic risk in these patients. Aim of the study. Evaluation of changes fibrinogen in patients with type 2 diabetes mellitus and nondiabetics in relation to coronary artery disease, effect of metabolic normalisation, sex, age, smoking, BMI and WHR on fibrinogen and assessment of independent coronary risk factors in the two study groups.
MATERIAL AND METHODS. The study was conducted in 114 patients, including 61 with type 2 diabetes mellitus, aged 58.6 ± 7.8 years, 26 males and 35 females, and 53 patients aged 53.2 ± 8.6 years, 20 males and 33 females, without carbohydrate abnormalities. Clinical and biochemical parameters were analysed. Plasma fibrinogen was measured using the modified Clauss method (Fibrintimer, Behringwerke).
RESULTS. Fibrinogen concentration in patients with diabetes mellitus and coronary artery disease was significantly higher than in diabetics without coronary artery disease (3.05 ± 0.75 vs. 2.45 ± 0.85 g/ P < 0.01) and in diabetics irrespective of the presence of coronary artery disease (2.61 ± 0.66 and 2.30 ± 0.56 g/l; P < 0.01). Multiple regression analysis revealed that smoking (P < 0.001) and age (P < 0.05) independently modify fibrinogen concentration. Multiple regression analysis also revealed that independent risk factors associated with coronary artery disease in diabetics are microalbuminuria (P < 0.01) and fibrinogen (P < 0.05), whereas nondiabetics it is total cholesterol (P < 0.05).
CONCLUSIONS. In this study type 2 diabetics with coronary artery disease had significantly higher fibrinogen concentration. Fibrinogen concentration was independently modified by smoking and age. Independent risk factors associated with coronary artery disease in diabetics were microalbuminuria and fibrinogen, whereas in nondiabetics it was total cholesterol.
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Keywords

type 2 diabetes mellitus; fibrinogen; coronary heart disease

About this article
Title

Fibrinogen as a coronary risk factor in patients with type 2 diabetes mellitus

Journal

Clinical Diabetology

Issue

Vol 4, No 4 (2003): Practical Diabetology

Pages

265-272

Published online

2003-09-18

Bibliographic record

Diabetologia Praktyczna 2003;4(4):265-272.

Keywords

type 2 diabetes mellitus
fibrinogen
coronary heart disease

Authors

Elżbieta Kozek
Tomasz Klupa
Przemysław Witek
Maciej Małecki
Jacek Sieradzki

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