Vol 5, No 1 (2004): Practical Diabetology
Review article
Published online: 2004-02-02
Hormonal replacement therapy in postmenopausal diabetic women
Diabetologia Praktyczna 2004;5(1):41-44.
Abstract
In postmenopausal women due to the lack of the
sex hormones occur the metabolic changes. Visceral
obesity, insulin resistance, dyslipidemia, hypertension
are the risk factors for cardiovascular diseases.
These factors create the menopausal metabolic
syndrome (syndrome X or syndrome W). After
menopause the number of women with diabetes
mellitus is growing up. Menopause and diabetes
cause to higher mortality of cardiovascular diseases.
Hormonal replacement therapy in diabetic postmenopausal
women should be “tailored”. Diabetic postmenopausal
women often suffer from endometrial
carcinoma, fatty liver, cholecystolithiasis, hypertension,
hipertriglycerydemia, insulin resistance. Hormone
replacement therapy should be provided
transdermal to avoid the above concomitant illnesses.
The progestagen which should be prescribed
by intact uterus should bind only progesterone’s
receptor (not glycocorticosteroid’s receptor).
Keywords: diabetes mellitus type 2hormonal replacement therapymenopausal syndrome