Hormonal replacement therapy in postmenopausal diabetic women

Abstract

In postmenopausal women due to the lack of the sex hormones occur the metabolic changes. Visceral obesity, insulin resistance, dyslipidemia, hypertension are the risk factors for cardiovascular diseases. These factors create the menopausal metabolic syndrome (syndrome X or syndrome W). After menopause the number of women with diabetes mellitus is growing up. Menopause and diabetes cause to higher mortality of cardiovascular diseases. Hormonal replacement therapy in diabetic postmenopausal women should be “tailored”. Diabetic postmenopausal women often suffer from endometrial carcinoma, fatty liver, cholecystolithiasis, hypertension, hipertriglycerydemia, insulin resistance. Hormone replacement therapy should be provided transdermal to avoid the above concomitant illnesses. The progestagen which should be prescribed by intact uterus should bind only progesterone’s receptor (not glycocorticosteroid’s receptor).