open access

Vol 5, No 5 (2004): Practical Diabetology
Original articles (submitted)
Published online: 2004-10-26
Get Citation

Predisposition to impaired glucose metabolism after GDM in women with normal oral glucose tolerance

Aneta Malinowska-Polubiec, Krzysztof Czajkowski, Agnieszka Sotowska
Diabetologia Praktyczna 2004;5(5):247-254.

open access

Vol 5, No 5 (2004): Practical Diabetology
Original articles (submitted)
Published online: 2004-10-26

Abstract

INTRODUCTION. Women with previous GDM also have a high risk of obesity, dyslipidemia, hypertension and atherosclerotic vascular disease. The aim of the study was to assess predisposition to disturbances of glucose metabolism in former GDM subjects with normal glucose tolerance at follow-up.
MATERIAL AND METHODS. Former GDM (n = 155) and control (n = 36) subjects were studied to a 75-g oral glucose tolerance test with measurements of insilin, C-peptide and lipid profile. GDM subjects with normal glucose tolerance at follow-up were compared with non-GDM.
RESULTS. A comparison between GDM subjects and control subjects with normal OGTT at follow-up demonstrated differences in gestational age (30 vs 26 years old) and pregestational weight (68 vs 60 kg) and BMI (25 vs 22 kg/m2). At follow-up GDM subjects have significantly higher whist circumstance (82 vs 76 cm), whist to hip ratio (0.8 vs 0.77), increased fasting insulin (9.5 vs 7 µg/dl), C-peptide (1.8 vs 1.5 ng/dl), and 1-h glucose in OGTT (153 vs 132 mg/dl). There were no significant differences in frequency of GADA between groups (16.7% vs 13.8%). Control subjects have significantly lower wieght gain from pregnancy to follow-up (2.8 vs 4.2 kg).
CONCLUSIONS. Women with previous GDM, despite normal glucose tolerance at follow-up, have a high risk of diabetes, because of high frequency of abdominal obesity and increased fasting insulin, C-peptide and 1-h glucose in OGTT. GDM sucjects compared with non-GDM are significantly more obese before pregnancy and older at delivery.

Abstract

INTRODUCTION. Women with previous GDM also have a high risk of obesity, dyslipidemia, hypertension and atherosclerotic vascular disease. The aim of the study was to assess predisposition to disturbances of glucose metabolism in former GDM subjects with normal glucose tolerance at follow-up.
MATERIAL AND METHODS. Former GDM (n = 155) and control (n = 36) subjects were studied to a 75-g oral glucose tolerance test with measurements of insilin, C-peptide and lipid profile. GDM subjects with normal glucose tolerance at follow-up were compared with non-GDM.
RESULTS. A comparison between GDM subjects and control subjects with normal OGTT at follow-up demonstrated differences in gestational age (30 vs 26 years old) and pregestational weight (68 vs 60 kg) and BMI (25 vs 22 kg/m2). At follow-up GDM subjects have significantly higher whist circumstance (82 vs 76 cm), whist to hip ratio (0.8 vs 0.77), increased fasting insulin (9.5 vs 7 µg/dl), C-peptide (1.8 vs 1.5 ng/dl), and 1-h glucose in OGTT (153 vs 132 mg/dl). There were no significant differences in frequency of GADA between groups (16.7% vs 13.8%). Control subjects have significantly lower wieght gain from pregnancy to follow-up (2.8 vs 4.2 kg).
CONCLUSIONS. Women with previous GDM, despite normal glucose tolerance at follow-up, have a high risk of diabetes, because of high frequency of abdominal obesity and increased fasting insulin, C-peptide and 1-h glucose in OGTT. GDM sucjects compared with non-GDM are significantly more obese before pregnancy and older at delivery.
Get Citation

Keywords

GDM (gestational diabetes mellitus); risk of diabetes; OGTT (oral glucose tolerance test)

About this article
Title

Predisposition to impaired glucose metabolism after GDM in women with normal oral glucose tolerance

Journal

Clinical Diabetology

Issue

Vol 5, No 5 (2004): Practical Diabetology

Pages

247-254

Published online

2004-10-26

Bibliographic record

Diabetologia Praktyczna 2004;5(5):247-254.

Keywords

GDM (gestational diabetes mellitus)
risk of diabetes
OGTT (oral glucose tolerance test)

Authors

Aneta Malinowska-Polubiec
Krzysztof Czajkowski
Agnieszka Sotowska

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl