Vol 5, No 5 (2004): Practical Diabetology
Other materials agreed with the Editors
Submitted: 2012-01-02
Published online: 2004-10-26
Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
Darcy B. Carr, Kristina M. Utzschneider, Rebecca L. Hull, Keiichi Kodama, Barbara M. Retzlaff, John D. Brunzell, Jane B. Shofer, Brian E. Fish, Robert H. Knopp, Steven E. Kahn
Diabetologia Praktyczna 2004;5(5):283-292.
Vol 5, No 5 (2004): Practical Diabetology
Original articles (translated)
Submitted: 2012-01-02
Published online: 2004-10-26
Abstract
The underlying pathophysiology of the metabolic
syndrome is the subject of debate, with both insulin
resistance and obesity considered as important
factors. We evaluated the differential effects of insulin
resistance and central body fat distribution in
determining the metabolic syndrome as defined by
the National Cholesterol Education Program (NCEP)
Adult Treatment Panel III. In addition, we determined
which NCEP criteria were associated with insulin
resistance and central adiposity. The subjects,
218 healthy men (n = 89) and women (n = 129)
with a broad range of age (26–75 years) and BMI
(18.4–46.8 kg/m2), underwent quantification of the
insulin sensitivity index (Si) and intra-abdominal fat
(IAF) and subcutaneous fat (SCF) areas. The metabolic
syndrome was present in 34 (15.6%) of subjects
who had a lower Si [median: 3.13 vs. 6.09 ×
× 10–5 min–1/(pmol/l)] and higher IAF (166.3 vs. 79.1 cm2)
and SCF (285.1 vs. 179.8 cm2) areas compared with
subjects without the syndrome (P < 0.001). Multivariate
models including Si, IAF, and SCF demonstrated
that each parameter was associated with the
syndrome. However, IAF was independently associated
with all five of the metabolic syndrome criteria.
In multivariable models containing the criteria
as covariates, waist circumference and triglyceride
levels were independently associated with Si and IAF
and SCF areas (P < 0.001). Although insulin resistance
and central body fat are both associated with the
metabolic syndrome, IAF is independently associated
with all of the criteria, suggesting that it may have
a pathophysiological role. Of the NCEP criteria, waist
circumference and triglycerides may best identify insulin
resistance and visceral adiposity in individuals
with a fasting plasma glucose < 6.4 mmol/l.
Abstract
The underlying pathophysiology of the metabolic
syndrome is the subject of debate, with both insulin
resistance and obesity considered as important
factors. We evaluated the differential effects of insulin
resistance and central body fat distribution in
determining the metabolic syndrome as defined by
the National Cholesterol Education Program (NCEP)
Adult Treatment Panel III. In addition, we determined
which NCEP criteria were associated with insulin
resistance and central adiposity. The subjects,
218 healthy men (n = 89) and women (n = 129)
with a broad range of age (26–75 years) and BMI
(18.4–46.8 kg/m2), underwent quantification of the
insulin sensitivity index (Si) and intra-abdominal fat
(IAF) and subcutaneous fat (SCF) areas. The metabolic
syndrome was present in 34 (15.6%) of subjects
who had a lower Si [median: 3.13 vs. 6.09 ×
× 10–5 min–1/(pmol/l)] and higher IAF (166.3 vs. 79.1 cm2)
and SCF (285.1 vs. 179.8 cm2) areas compared with
subjects without the syndrome (P < 0.001). Multivariate
models including Si, IAF, and SCF demonstrated
that each parameter was associated with the
syndrome. However, IAF was independently associated
with all five of the metabolic syndrome criteria.
In multivariable models containing the criteria
as covariates, waist circumference and triglyceride
levels were independently associated with Si and IAF
and SCF areas (P < 0.001). Although insulin resistance
and central body fat are both associated with the
metabolic syndrome, IAF is independently associated
with all of the criteria, suggesting that it may have
a pathophysiological role. Of the NCEP criteria, waist
circumference and triglycerides may best identify insulin
resistance and visceral adiposity in individuals
with a fasting plasma glucose < 6.4 mmol/l.
Keywords
metabolic syndrome; central adiposity; insulin sensitivity; intra-abdominal fat
Title
Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
Journal
Clinical Diabetology
Issue
Vol 5, No 5 (2004): Practical Diabetology
Article type
Other materials agreed with the Editors
Pages
283-292
Published online
2004-10-26
Page views
606
Bibliographic record
Diabetologia Praktyczna 2004;5(5):283-292.
Keywords
metabolic syndrome
central adiposity
insulin sensitivity
intra-abdominal fat
Authors
Darcy B. Carr
Kristina M. Utzschneider
Rebecca L. Hull
Keiichi Kodama
Barbara M. Retzlaff
John D. Brunzell
Jane B. Shofer
Brian E. Fish
Robert H. Knopp
Steven E. Kahn
About this article