Vol 6, No 1 (2005): Practical Diabetology
Research paper
Published online: 2005-02-17

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Efficacy, tolerability, and safety of Amaryl (glimepiride). Multicenter, retrospective, polish cohort study

Ida Kinalska, Jan M. Wójcicki
Diabetologia Praktyczna 2005;6(1):21-28.


INTRODUCTION. Glimepiride is indicated for the treatment of type 2 diabetes mellitus. The aim of the present study was to monitor the tolerability and efficacy of glimepiride in Polish diabetic patients in daily practice.
MATERIAL AND METHODS. A 12-week non interventional cohort study in daily practice was performed. 2587 patients with type 2 diabetes mellitus were included into the study. The patients were treated with glimepiride for at least 3 months. In patients with pre-existing oral antihyperglicaemic medication the therapy was changed to glimepiride monotherapy.
RESULTS. The mean reduction of HbA1c (0.95%) was more significant in newly treated patients with glimepiride. Body weight was reduced (0.5 BMI). This effect was particulary observed in the obese patients. In 3,7% patients adverse events were observed including hypoglicaemia (0.64%).
CONCLUSION. This study carried out in Poland under daily practice confirmed the good tolerability and efficacy of glimepiride in the treatment of diabetic patients.

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