Vol 7, No 5 (2006): Practical Diabetology
Review article
Published online: 2006-09-28
Practical approach to the intensification of insulin therapy in type 2 diabetes mellitus - the algorithm of switch from biphasic human insulin to biphasic aspart insulin
Diabetologia Praktyczna 2006;7(5):295-299.
Abstract
In recent years, the need of intensifying and improving
metabolic control in type 2 diabetes is becoming
more and more important. The majority of
insulin treated type 2 patients in Poland receives human
insulin premixes that in many cases are not
sufficient to prevent diabetes complications, particularly
macroangiopathy as a consequence of inadequate
postprandial glycaemic control. Biphasic
insulin analogues seem to be a good tool to improve
diabetes control in those patients, they are
convenient to administer and provide appropriate
control the postprandial glycaemia peaks without
compromising hypoglycaemia risk. This paper contains
practical considerations and guidelines based
on authors clinical experience that could be helpful
in safe switching type 2 patients from human insulin
premixes to biphasic insulin aspart preparations.
Keywords: type 2 diabeteshuman insulinaspart insulinpremixed insulins