open access

Vol 8, No 4 (2007): Practical Diabetology
Original articles (submitted)
Published online: 2007-05-17
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Efficacy, safety and tolerability of glargine - long acting insulin analogue in adult patients with type 1 diabetes mellitus in everyday clinical practice

Mariusz Dąbrowski, Andrzej Nowakowski
Diabetologia Praktyczna 2007;8(4):113-121.

open access

Vol 8, No 4 (2007): Practical Diabetology
Original articles (submitted)
Published online: 2007-05-17

Abstract

INTRODUCTION. Incidence and prevalence of type 1 diabetes in Poland are still increasing. Methods of treatment and achieved metabolic control have a great impact on prognosis in this disease. In this retrospective observational study efficacy, safety and tolerability of long-acting insulin analogue, glargine in everyday clinical practice were evaluated.
MATERIAL AND METHODS. 68 persons with type 1 diabetes were observed. Main indications for treatment with glargine were morning hyperglycemia, nocturnal hypoglycemia and large fluctuations of glucose level during 24 hours. During the study impact of treatment with glargine on metabolic control, frequency of hypoglycemia, body mass, blood pressure and treatment satisfaction was evaluated. Also changes in insulin doses were calculated.
RESULTS. During the observation lasting 22.0 ± 12.2 months, 0.53% significant decrease of HbA1C (from 8.56% to 8.03%) (p = 0.00014) was achieved. Frequency of hypoglycemia also decreased. Impact on body mass was neutral (66.5 kg before treatment and 67.2 kg at the end of observation) and blood pressure values didn’t change significantly (131.4/79.4 mm Hg vs. 132.1/79.3 mm Hg). Requirement for basal insulin dose has lowered significantly at the end of the observation (from 22.1 units to 17.4 units) (p < 0.00001), also total insulin dose decreased significantly from 49.2 to 45.9 units (p = 0.005).
CONCLUSIONS. In this study long-acting insulin analogue-glargine, was characterized by good efficacy, very good safety profile and was much better tolerated as compared with previous treatment. Moreover it didn't has negative impact on body mass and blood pressure.

Abstract

INTRODUCTION. Incidence and prevalence of type 1 diabetes in Poland are still increasing. Methods of treatment and achieved metabolic control have a great impact on prognosis in this disease. In this retrospective observational study efficacy, safety and tolerability of long-acting insulin analogue, glargine in everyday clinical practice were evaluated.
MATERIAL AND METHODS. 68 persons with type 1 diabetes were observed. Main indications for treatment with glargine were morning hyperglycemia, nocturnal hypoglycemia and large fluctuations of glucose level during 24 hours. During the study impact of treatment with glargine on metabolic control, frequency of hypoglycemia, body mass, blood pressure and treatment satisfaction was evaluated. Also changes in insulin doses were calculated.
RESULTS. During the observation lasting 22.0 ± 12.2 months, 0.53% significant decrease of HbA1C (from 8.56% to 8.03%) (p = 0.00014) was achieved. Frequency of hypoglycemia also decreased. Impact on body mass was neutral (66.5 kg before treatment and 67.2 kg at the end of observation) and blood pressure values didn’t change significantly (131.4/79.4 mm Hg vs. 132.1/79.3 mm Hg). Requirement for basal insulin dose has lowered significantly at the end of the observation (from 22.1 units to 17.4 units) (p < 0.00001), also total insulin dose decreased significantly from 49.2 to 45.9 units (p = 0.005).
CONCLUSIONS. In this study long-acting insulin analogue-glargine, was characterized by good efficacy, very good safety profile and was much better tolerated as compared with previous treatment. Moreover it didn't has negative impact on body mass and blood pressure.
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Keywords

type 1 diabetes; insulin glargine; metabolic control; hypoglycemia

About this article
Title

Efficacy, safety and tolerability of glargine - long acting insulin analogue in adult patients with type 1 diabetes mellitus in everyday clinical practice

Journal

Clinical Diabetology

Issue

Vol 8, No 4 (2007): Practical Diabetology

Pages

113-121

Published online

2007-05-17

Bibliographic record

Diabetologia Praktyczna 2007;8(4):113-121.

Keywords

type 1 diabetes
insulin glargine
metabolic control
hypoglycemia

Authors

Mariusz Dąbrowski
Andrzej Nowakowski

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