open access

Vol 8, No 5 (2007): Practical Diabetology
Review articles (submitted)
Published online: 2007-05-24
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The role of osteoprotegerin/RANKL/RANK axis in diabetes complications and coronary heart disease

Anna Korzon-Burakowska, Sławomir Burakowski
Diabetologia Praktyczna 2007;8(5):161-164.

open access

Vol 8, No 5 (2007): Practical Diabetology
Review articles (submitted)
Published online: 2007-05-24

Abstract

Osteoprotegerin and RANKL are cytokines belonging to the TNF family which regulate osteoclastogenesis and may play role in vascular calcification. Abnormalities in osteoprotegerin/RANKL/RANK system have been described in many diseases. Recent clinical studies suggest significant correlation between elevated serum OPG levels and coronary artery disease as well as cardiovascular mortality. Increased OPG levels were also observed in patients with diabetes and in subjects with diabetes and microangiopathy. Charcot arthropathy is characterized by the presence of osteopenia and vascular calcification. OPG and RANKL - as cytokines involved in both processes - may play a significant role in the pathogenesis of this complication

Abstract

Osteoprotegerin and RANKL are cytokines belonging to the TNF family which regulate osteoclastogenesis and may play role in vascular calcification. Abnormalities in osteoprotegerin/RANKL/RANK system have been described in many diseases. Recent clinical studies suggest significant correlation between elevated serum OPG levels and coronary artery disease as well as cardiovascular mortality. Increased OPG levels were also observed in patients with diabetes and in subjects with diabetes and microangiopathy. Charcot arthropathy is characterized by the presence of osteopenia and vascular calcification. OPG and RANKL - as cytokines involved in both processes - may play a significant role in the pathogenesis of this complication
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Keywords

osteoprotegerin; vascular calcification; coronary artery disease; diabetes mellitus; Charcot arthropathy

About this article
Title

The role of osteoprotegerin/RANKL/RANK axis in diabetes complications and coronary heart disease

Journal

Clinical Diabetology

Issue

Vol 8, No 5 (2007): Practical Diabetology

Pages

161-164

Published online

2007-05-24

Bibliographic record

Diabetologia Praktyczna 2007;8(5):161-164.

Keywords

osteoprotegerin
vascular calcification
coronary artery disease
diabetes mellitus
Charcot arthropathy

Authors

Anna Korzon-Burakowska
Sławomir Burakowski

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