open access

Vol 8, No 7 (2007): Practical Diabetology
Review articles (translated)
Published online: 2007-08-01
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Hypothesis: the "metabolic memory" - the new challenge of diabetes

M.A. Ihnat, J.E. Thorpe, A. Ceriello
Diabetologia Praktyczna 2007;8(7):289-294.

open access

Vol 8, No 7 (2007): Practical Diabetology
Review articles (translated)
Published online: 2007-08-01

Abstract

Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro- and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as 'metabolic memory'. Potential mechanisms for propagating this 'memory' are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signalling. Furthermore, the emergence of this 'metabolic memory' suggests the need for very early aggressive treatment aiming to 'normalize' glycaemic control and the addition of agents which reduce cellular reactive species and glycation in order to minimize long-term diabetic complications.

Abstract

Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro- and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as 'metabolic memory'. Potential mechanisms for propagating this 'memory' are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signalling. Furthermore, the emergence of this 'metabolic memory' suggests the need for very early aggressive treatment aiming to 'normalize' glycaemic control and the addition of agents which reduce cellular reactive species and glycation in order to minimize long-term diabetic complications.
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Keywords

diabetic complications; metabolic memory; mitochondria; nonenzymatic glycation; oxidative stress

About this article
Title

Hypothesis: the "metabolic memory" - the new challenge of diabetes

Journal

Clinical Diabetology

Issue

Vol 8, No 7 (2007): Practical Diabetology

Pages

289-294

Published online

2007-08-01

Bibliographic record

Diabetologia Praktyczna 2007;8(7):289-294.

Keywords

diabetic complications
metabolic memory
mitochondria
nonenzymatic glycation
oxidative stress

Authors

M.A. Ihnat
J.E. Thorpe
A. Ceriello

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