Vol 9, No 2 (2008): Practical Diabetology
Research paper
Published online: 2008-05-13

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The incidence of risk factors of type 2 diabetes mellitus in relatives of the patients

Agata Bronisz, Katarzyna Rotkiewicz, Elżbieta Głuch, Marta Pilaczyńska-Cemel, Aleksandra Słonina, Marek Bronisz, Justyna Jaraczewska, Agnieszka Radziejewska, Anna Ruszkiewicz, Roman Junik
Diabetologia Praktyczna 2008;9(2):82-88.

Abstract

INTRODUCTION. The aim of the study was the evaluation of glucose metabolism disturbances in I° relatives of the patients with type 2 diabetes, depending on the other present risk factors.
MATERIAL AND METHODS. The evaluated group consisted of 42 I° relatives of the patients treated in Outpatient Diabetology Clinic of the University Hospital in Bydgoszcz. A subjective, objective examination and the oral glucose tolerance test were carried out.
RESULTS. In 13 patients (31%) glucose metabolism disturbances (ZGW group) were identified, in 29 they were not stated (BZGW group). The examined ZGW group patients were considerably statistically older than the BZGW (59.8 ± 14.6 vs. 37.8 ± 15.5 years; p < 0.001), had a remarkably greater inherited susceptibility to type 2 diabetes (2.0 ± 1.1 vs. 1.1 ± ± 0.4; p < 0.001 of the number of relatives in the family) and were characterized by a significantly higher number of the diabetes risk factors (2.9 ± 1.2 vs. 2.0 ± 1.2; p < 0.01). The occurrence of the abnormal glycaemia - 61.5% (BZGW - 6.9%) in the anamnesis turned out to be the most common and statistically important. Both groups did not differ in the number of parents with diabetes, whereas 92.3% patients of the ZGW and only 13.8% of the BZGW had siblings with diabetes. 23% people with ZGW had at least one child with diabetes while no-one thase with BZGW. No significant differences between the groups, regarding BMI were stated: 28.3 ± 4.5 kg/m2 versus 25.9 ± 4.9 kg/m2 and WHR: 0.86 ± 0.08 versus 0.83 ± ± 0.07 respectively. Gestational diabetes mellitus occurred in 7.7% versus 6.9%, giving birth to a newborn with birth weight above 4000 g: 7.7% versus 11.9%, polycystic ovary syndrome: 7.7% versus 3.4%.
CONCLUSIONS. In the I° relatives of the patients with type 2 diabetes the occurrence of glucose metabolism disturbances depended on: age, the amount of diabetes risk factors, especially stating abnormal glycaemia values in the anamnesis, the number of relatives with type 2 diabetes, siblings and children in particular.

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