open access

Vol 9, No 2 (2008): Practical Diabetology
Research paper
Submitted: 2012-01-02
Published online: 2008-05-13
Get Citation

The assessment of C reactive protein during pregnancy complicated by gestational diabetes mellitus

Katarzyna Cyganek, Alicja Hebda-Szydło, Barbara Katra, Paweł Wołkow, Irena Kaim, Jacek Sieradzki
DOI: 10.5603/cd.8461
·
Diabetologia Praktyczna 2008;9(2):70-75.

open access

Vol 9, No 2 (2008): Practical Diabetology
Original articles
Submitted: 2012-01-02
Published online: 2008-05-13

Abstract

INTRODUCTION. The aim of the article is to asses metabolic changes in pregnant women with gestational diabetes and compare to healthy women as well as to determine whether GDM is characterized by relative changes in C-reactive protein (CRP) level.
MATERIAL AND METHODS. We performed a crosssectional study that included 335 pregnant women, all of the Caucasian race. They underwent oral glucose tolerance test (OGTT) in the late second or early third trimester. Based on OGTT, the participants were stratified into GDM group (n = 260) and normal glucose tolerance (NGT) group (n = 75). Insulin, C-peptide, HbA1C and CRP level were evaluated.
RESULTS. Those groups did not differ in age and body weight before and after pregnancy. We did not find any differences between GDM and NGT groups in respect to the level of HbA1C (respectively: 5.04 ± ± 0.5 vs. 4.96 ± 0.4%; p = 0.2) and C-peptide level (respectively: 2.5 ± 1.4 vs. 2.4 ± 1.2 ng/ml; p = 0.5). We did not find statistical differences between CRP level in both groups, however we observed a slightly higher level of CRP in GDM group (respectively: 5.47 ± 7.1 vs. 4.0 ± 3.1 mg/l; p = 0.2). There were differences in frequency of overweight and obesity favouring GDM group as compared to NGT (p = 0.03). We performed additional analysis based on prepregnancy body mass index (BMI). Participants were stratified into groups with normal body weight (1), overweight (2) and obesity (3). CRP level was statistically elevated in obese participants as compared to lean ones in both GDM (respectively: 4.7 ± 8.1 vs. 5.9 ± ± 6.1 mg/l; p = 0.4 and 4.7 ± 8.1 vs. 7.7 ± 5.6 mg/l; p = 0.04) and NGT groups (respectively: 3.2 ± 2.8 vs. 4.2 ± 2.4 mg/l; p = 0.3 and 3.2 ± 2.8 vs. 5.4 ± ± 2.1 mg/l; p = 0.04).
CONCLUSIONS. Our data suggest that inflammatory status is more associated with obesity than diabetes during pregnancy and obesity my play a key role in mediating insulin resistance in gestational diabetes.

Abstract

INTRODUCTION. The aim of the article is to asses metabolic changes in pregnant women with gestational diabetes and compare to healthy women as well as to determine whether GDM is characterized by relative changes in C-reactive protein (CRP) level.
MATERIAL AND METHODS. We performed a crosssectional study that included 335 pregnant women, all of the Caucasian race. They underwent oral glucose tolerance test (OGTT) in the late second or early third trimester. Based on OGTT, the participants were stratified into GDM group (n = 260) and normal glucose tolerance (NGT) group (n = 75). Insulin, C-peptide, HbA1C and CRP level were evaluated.
RESULTS. Those groups did not differ in age and body weight before and after pregnancy. We did not find any differences between GDM and NGT groups in respect to the level of HbA1C (respectively: 5.04 ± ± 0.5 vs. 4.96 ± 0.4%; p = 0.2) and C-peptide level (respectively: 2.5 ± 1.4 vs. 2.4 ± 1.2 ng/ml; p = 0.5). We did not find statistical differences between CRP level in both groups, however we observed a slightly higher level of CRP in GDM group (respectively: 5.47 ± 7.1 vs. 4.0 ± 3.1 mg/l; p = 0.2). There were differences in frequency of overweight and obesity favouring GDM group as compared to NGT (p = 0.03). We performed additional analysis based on prepregnancy body mass index (BMI). Participants were stratified into groups with normal body weight (1), overweight (2) and obesity (3). CRP level was statistically elevated in obese participants as compared to lean ones in both GDM (respectively: 4.7 ± 8.1 vs. 5.9 ± ± 6.1 mg/l; p = 0.4 and 4.7 ± 8.1 vs. 7.7 ± 5.6 mg/l; p = 0.04) and NGT groups (respectively: 3.2 ± 2.8 vs. 4.2 ± 2.4 mg/l; p = 0.3 and 3.2 ± 2.8 vs. 5.4 ± ± 2.1 mg/l; p = 0.04).
CONCLUSIONS. Our data suggest that inflammatory status is more associated with obesity than diabetes during pregnancy and obesity my play a key role in mediating insulin resistance in gestational diabetes.
Get Citation

Keywords

gestational diabetes; C-reactive protein; obesity

About this article
Title

The assessment of C reactive protein during pregnancy complicated by gestational diabetes mellitus

Journal

Clinical Diabetology

Issue

Vol 9, No 2 (2008): Practical Diabetology

Article type

Research paper

Pages

70-75

Published online

2008-05-13

Page views

1179

Article views/downloads

1623

DOI

10.5603/cd.8461

Bibliographic record

Diabetologia Praktyczna 2008;9(2):70-75.

Keywords

gestational diabetes
C-reactive protein
obesity

Authors

Katarzyna Cyganek
Alicja Hebda-Szydło
Barbara Katra
Paweł Wołkow
Irena Kaim
Jacek Sieradzki

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

 

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl