open access
The assessment of C reactive protein during pregnancy complicated by gestational diabetes mellitus
open access
Abstract
MATERIAL AND METHODS. We performed a crosssectional study that included 335 pregnant women, all of the Caucasian race. They underwent oral glucose tolerance test (OGTT) in the late second or early third trimester. Based on OGTT, the participants were stratified into GDM group (n = 260) and normal glucose tolerance (NGT) group (n = 75). Insulin, C-peptide, HbA1C and CRP level were evaluated.
RESULTS. Those groups did not differ in age and body weight before and after pregnancy. We did not find any differences between GDM and NGT groups in respect to the level of HbA1C (respectively: 5.04 ± ± 0.5 vs. 4.96 ± 0.4%; p = 0.2) and C-peptide level (respectively: 2.5 ± 1.4 vs. 2.4 ± 1.2 ng/ml; p = 0.5). We did not find statistical differences between CRP level in both groups, however we observed a slightly higher level of CRP in GDM group (respectively: 5.47 ± 7.1 vs. 4.0 ± 3.1 mg/l; p = 0.2). There were differences in frequency of overweight and obesity favouring GDM group as compared to NGT (p = 0.03). We performed additional analysis based on prepregnancy body mass index (BMI). Participants were stratified into groups with normal body weight (1), overweight (2) and obesity (3). CRP level was statistically elevated in obese participants as compared to lean ones in both GDM (respectively: 4.7 ± 8.1 vs. 5.9 ± ± 6.1 mg/l; p = 0.4 and 4.7 ± 8.1 vs. 7.7 ± 5.6 mg/l; p = 0.04) and NGT groups (respectively: 3.2 ± 2.8 vs. 4.2 ± 2.4 mg/l; p = 0.3 and 3.2 ± 2.8 vs. 5.4 ± ± 2.1 mg/l; p = 0.04).
CONCLUSIONS. Our data suggest that inflammatory status is more associated with obesity than diabetes during pregnancy and obesity my play a key role in mediating insulin resistance in gestational diabetes.
Abstract
MATERIAL AND METHODS. We performed a crosssectional study that included 335 pregnant women, all of the Caucasian race. They underwent oral glucose tolerance test (OGTT) in the late second or early third trimester. Based on OGTT, the participants were stratified into GDM group (n = 260) and normal glucose tolerance (NGT) group (n = 75). Insulin, C-peptide, HbA1C and CRP level were evaluated.
RESULTS. Those groups did not differ in age and body weight before and after pregnancy. We did not find any differences between GDM and NGT groups in respect to the level of HbA1C (respectively: 5.04 ± ± 0.5 vs. 4.96 ± 0.4%; p = 0.2) and C-peptide level (respectively: 2.5 ± 1.4 vs. 2.4 ± 1.2 ng/ml; p = 0.5). We did not find statistical differences between CRP level in both groups, however we observed a slightly higher level of CRP in GDM group (respectively: 5.47 ± 7.1 vs. 4.0 ± 3.1 mg/l; p = 0.2). There were differences in frequency of overweight and obesity favouring GDM group as compared to NGT (p = 0.03). We performed additional analysis based on prepregnancy body mass index (BMI). Participants were stratified into groups with normal body weight (1), overweight (2) and obesity (3). CRP level was statistically elevated in obese participants as compared to lean ones in both GDM (respectively: 4.7 ± 8.1 vs. 5.9 ± ± 6.1 mg/l; p = 0.4 and 4.7 ± 8.1 vs. 7.7 ± 5.6 mg/l; p = 0.04) and NGT groups (respectively: 3.2 ± 2.8 vs. 4.2 ± 2.4 mg/l; p = 0.3 and 3.2 ± 2.8 vs. 5.4 ± ± 2.1 mg/l; p = 0.04).
CONCLUSIONS. Our data suggest that inflammatory status is more associated with obesity than diabetes during pregnancy and obesity my play a key role in mediating insulin resistance in gestational diabetes.
Keywords
gestational diabetes; C-reactive protein; obesity


Title
The assessment of C reactive protein during pregnancy complicated by gestational diabetes mellitus
Journal
Issue
Vol 9, No 2 (2008): Practical Diabetology
Article type
Research paper
Pages
70-75
Published online
2008-05-13
Page views
1179
Article views/downloads
1623
DOI
10.5603/cd.8461
Bibliographic record
Diabetologia Praktyczna 2008;9(2):70-75.
Keywords
gestational diabetes
C-reactive protein
obesity
Authors
Katarzyna Cyganek
Alicja Hebda-Szydło
Barbara Katra
Paweł Wołkow
Irena Kaim
Jacek Sieradzki