open access

Vol 9, No 3-4 (2008): Practical Diabetology
Original articles (submitted)
Published online: 2008-07-04
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Changes in adiponectine concentration in blood serum of obese type 2 diabetes patients in relation to renal function

Iwona Jakubowska, Jolanta Czyżewska, Halina Kemona
Diabetologia Praktyczna 2008;9(3-4):113-120.

open access

Vol 9, No 3-4 (2008): Practical Diabetology
Original articles (submitted)
Published online: 2008-07-04

Abstract

INTRODUCTION. The aim of this work is to assess the concentration of adiponectine in the blood serum of obese type 2 diabetes patients with normal and impaired renal function in comparison to a control group of obese people without diabetes and with normal renal function.
MATERIALS AND METHODS. Two groups of obese type 2 diabetes patients and regular renal function (group A - 16 patients) or renal insufficiency (group B - 15 patients) were analysed. The research included patients with at least ten years of recorded type 2 diabetes, treated with insulin. The groups were divided according to the concentration of creatinine of 1.5 mg/dl. The control group consisted of people with obesity, but no diabetes, with normal renal function. They all had their body mass measured, as well as the concentration of HbA1c, creatinin, adiponectine, lipid profile. The statistical analysis was performed with the use of the Mann-Whitney test for quantitative comparison and Fisher’s exact test for the assessment of frequency of occurrence of quantitative parameters. Non-parametric Spearman correlations were evaluated for all quantitative parameters.
RESULTS. The average concentration of adiponectine in group A was 77.7 mg/ml, 93.6 mg/ml in group B and 109.4 mg/ml in the control group. The differences were only statistically relevant between group A and the control (p = 0.023). The analysis of the correlation between adiponectine concentration and other parameters has shown a statistically relevant correlation between adiponectine concentration and body mass [r(-) 0.49; p = 0,000] and between adiponectine concentration and BMI [r(-) 33; p = 0.018]. With the parameters divided into two groups of patients there was a statistically relevant correlation only between adiponectine concentration and body mass in the control group [r(-); p = 0.015] and in group A [r(-) 0.51; p = 0.045]. The correlation between adiponectine concentration and creatinin clearance was also close to statistical relevance [r(-) 0.47; p = 0.055]. The concentrations of HbA1c were similar and showed no statistical relevance. The difference in the concentration of HDL and LDL cholesterol was statistically relevant in group B as compared to the control (HDL: p = 0.004; LDL: p = 0.035). Differences in the concentration of various lipids were not statistically relevant. In comparison to the control group the frequency of hypertension was statistically relevant in both group A (p = 0.001) and group B (p = 0.005). A statistically relevant difference in the frequency of circulatory insufficiency is observed in both groups of patients (group A - 25%, group B - 66,7%; p = 0.032) and in the comparison between group B and control (p = 0.001).
CONCLUSIONS. The development of renal insufficiency in diabetes leads to an increase in adiponectine concentration in blood serum. Obese patients with type 2 diabetes show a lower concentration of adiponectine than obese people with no diabetes. There is no indication of an influence of metabolic homeostasis on adiponectine concentration.

Abstract

INTRODUCTION. The aim of this work is to assess the concentration of adiponectine in the blood serum of obese type 2 diabetes patients with normal and impaired renal function in comparison to a control group of obese people without diabetes and with normal renal function.
MATERIALS AND METHODS. Two groups of obese type 2 diabetes patients and regular renal function (group A - 16 patients) or renal insufficiency (group B - 15 patients) were analysed. The research included patients with at least ten years of recorded type 2 diabetes, treated with insulin. The groups were divided according to the concentration of creatinine of 1.5 mg/dl. The control group consisted of people with obesity, but no diabetes, with normal renal function. They all had their body mass measured, as well as the concentration of HbA1c, creatinin, adiponectine, lipid profile. The statistical analysis was performed with the use of the Mann-Whitney test for quantitative comparison and Fisher’s exact test for the assessment of frequency of occurrence of quantitative parameters. Non-parametric Spearman correlations were evaluated for all quantitative parameters.
RESULTS. The average concentration of adiponectine in group A was 77.7 mg/ml, 93.6 mg/ml in group B and 109.4 mg/ml in the control group. The differences were only statistically relevant between group A and the control (p = 0.023). The analysis of the correlation between adiponectine concentration and other parameters has shown a statistically relevant correlation between adiponectine concentration and body mass [r(-) 0.49; p = 0,000] and between adiponectine concentration and BMI [r(-) 33; p = 0.018]. With the parameters divided into two groups of patients there was a statistically relevant correlation only between adiponectine concentration and body mass in the control group [r(-); p = 0.015] and in group A [r(-) 0.51; p = 0.045]. The correlation between adiponectine concentration and creatinin clearance was also close to statistical relevance [r(-) 0.47; p = 0.055]. The concentrations of HbA1c were similar and showed no statistical relevance. The difference in the concentration of HDL and LDL cholesterol was statistically relevant in group B as compared to the control (HDL: p = 0.004; LDL: p = 0.035). Differences in the concentration of various lipids were not statistically relevant. In comparison to the control group the frequency of hypertension was statistically relevant in both group A (p = 0.001) and group B (p = 0.005). A statistically relevant difference in the frequency of circulatory insufficiency is observed in both groups of patients (group A - 25%, group B - 66,7%; p = 0.032) and in the comparison between group B and control (p = 0.001).
CONCLUSIONS. The development of renal insufficiency in diabetes leads to an increase in adiponectine concentration in blood serum. Obese patients with type 2 diabetes show a lower concentration of adiponectine than obese people with no diabetes. There is no indication of an influence of metabolic homeostasis on adiponectine concentration.
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Keywords

adiponectin; type 2 diabetes; obesity; insulin resistance; renal failure

About this article
Title

Changes in adiponectine concentration in blood serum of obese type 2 diabetes patients in relation to renal function

Journal

Clinical Diabetology

Issue

Vol 9, No 3-4 (2008): Practical Diabetology

Pages

113-120

Published online

2008-07-04

Bibliographic record

Diabetologia Praktyczna 2008;9(3-4):113-120.

Keywords

adiponectin
type 2 diabetes
obesity
insulin resistance
renal failure

Authors

Iwona Jakubowska
Jolanta Czyżewska
Halina Kemona

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