INTRODUCTION. The aim of this work is to assess the concentration of adiponectine in the blood serum of obese type 2 diabetes patients with normal and impaired renal function in comparison to a control group of obese people without diabetes and with normal renal function.
MATERIALS AND METHODS. Two groups of obese type 2 diabetes patients and regular renal function (group A - 16 patients) or renal insufficiency (group B - 15 patients) were analysed. The research included patients with at least ten years of recorded type 2 diabetes, treated with insulin. The groups were divided according to the concentration of creatinine of 1.5 mg/dl. The control group consisted of people with obesity, but no diabetes, with normal renal function. They all had their body mass measured, as well as the concentration of HbA_1c, creatinin, adiponectine, lipid profile. The statistical analysis was performed with the use of the Mann-Whitney test for quantitative comparison and Fisher’s exact test for the assessment of frequency of occurrence of quantitative parameters. Non-parametric Spearman correlations were evaluated for all quantitative parameters.
RESULTS. The average concentration of adiponectine in group A was 77.7 mg/ml, 93.6 mg/ml in group B and 109.4 mg/ml in the control group. The differences were only statistically relevant between group A and the control (p = 0.023). The analysis of the correlation between adiponectine concentration and other parameters has shown a statistically relevant correlation between adiponectine concentration and body mass [r(-) 0.49; p = 0,000] and between adiponectine concentration and BMI [r(-) 33; p = 0.018]. With the parameters divided into two groups of patients there was a statistically relevant correlation only between adiponectine concentration and body mass in the control group [r(-); p = 0.015] and in group A [r(-) 0.51; p = 0.045]. The correlation between adiponectine concentration and creatinin clearance was also close to statistical relevance [r(-) 0.47; p = 0.055]. The concentrations of HbA1c were similar and showed no statistical relevance. The difference in the concentration of HDL and LDL cholesterol was statistically relevant in group B as compared to the control (HDL: p = 0.004; LDL: p = 0.035). Differences in the concentration of various lipids were not statistically relevant. In comparison to the control group the frequency of hypertension was statistically relevant in both group A (p = 0.001) and group B (p = 0.005). A statistically relevant difference in the frequency of circulatory insufficiency is observed in both groups of patients (group A - 25%, group B - 66,7%; p = 0.032) and in the comparison between group B and control (p = 0.001).
CONCLUSIONS. The development of renal insufficiency in diabetes leads to an increase in adiponectine concentration in blood serum. Obese patients with type 2 diabetes show a lower concentration of adiponectine than obese people with no diabetes. There is no indication of an influence of metabolic homeostasis on adiponectine concentration.