Hyperhomocysteinemia in type 2 diabetic patients - still is considered as a risk factor or it’s only marker of atherosclerosis?

Abstract

Hyperhomocysteinemia is a pathological phenomenon markedly associated with atherosclerosis and atherosclerosis-related diseases development. Patients with diabetes type 2 are especially affected by hiperhomocysteinemia. However, there is quite a lot of doubts if hiperhomocysteinemia should be considered as atherosclerotic risk factor or it’s only marker of atherosclerosis. The elucidation of this problem could be of great practical importance and could allow to express adequate therapeutic recommendations. The manuscript contains the review of the most essential data concerning homocysteine biological properties, the reasons of hyperhomocysteinemia and results of studies focused on the relationship between hyperhomocysteinemia and atherosclerosis in type 2 diabetic patients.