open access

Vol 9, No 3-4 (2008): Practical Diabetology
Review articles (submitted)
Published online: 2008-07-04
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The impact of IL-12 on the process of development and occurrence of diabetes type 1

Małgorzata Wegner, Maria Pioruńska-Stolzmann
Diabetologia Praktyczna 2008;9(3-4):176-181.

open access

Vol 9, No 3-4 (2008): Practical Diabetology
Review articles (submitted)
Published online: 2008-07-04

Abstract

Interleukin 12 is a glycoprotein composed of two subunits: p35 and p40. The contribution of IL-12 in immune response is complex: the cytokine induces cell-mediated immunity but plays a role also in humoral response. IL-12 takes an important role in pathogenesis of autoimmune diseases, like diabetes type 1. IL-12 through activating differentiation Th0 in Th1, which products high levels of interferon gamma activates cytotoxic properties of NK cells and macrophages. It leads to development of the diabetes type 1. IL-12 activity also promotes atherosclerotic plaque formation leading to macroangiopathy development.

Abstract

Interleukin 12 is a glycoprotein composed of two subunits: p35 and p40. The contribution of IL-12 in immune response is complex: the cytokine induces cell-mediated immunity but plays a role also in humoral response. IL-12 takes an important role in pathogenesis of autoimmune diseases, like diabetes type 1. IL-12 through activating differentiation Th0 in Th1, which products high levels of interferon gamma activates cytotoxic properties of NK cells and macrophages. It leads to development of the diabetes type 1. IL-12 activity also promotes atherosclerotic plaque formation leading to macroangiopathy development.
Get Citation

Keywords

diabetes type 1; IL-12; immune response; atherosclerosis

About this article
Title

The impact of IL-12 on the process of development and occurrence of diabetes type 1

Journal

Clinical Diabetology

Issue

Vol 9, No 3-4 (2008): Practical Diabetology

Pages

176-181

Published online

2008-07-04

Bibliographic record

Diabetologia Praktyczna 2008;9(3-4):176-181.

Keywords

diabetes type 1
IL-12
immune response
atherosclerosis

Authors

Małgorzata Wegner
Maria Pioruńska-Stolzmann

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