Vol 9, No 3-4 (2008): Practical Diabetology
Review article
Published online: 2008-07-04
Diabetes of type LADA - definition, diagnostics and treatment
Diabetologia Praktyczna 2008;9(3-4):145-151.
Abstract
LADA is a form of autoimmune-mediated diabetes
inadults. The progression of beta-cell failure is slower than in childhood type 1 diabetes. Patients with
LADA present with more preserved beta-cell function
than hose with classic type1 diabetes. The diagnosis
of LADA according to Immunology Diabetes
Society is based on three features: age over 35 years,
the presence at least one of four circulating autoantibodies
to pancreatic islet cell antigens and lack of
requirement for insulin at least 6 month after diagnosis.
The level of C-peptide secretion after stimulation
with intravenous helped to diagnosis. There
are different opinions in relation to treatmen of
LADA. Some studies sugest, that insulin treatment
is indicated at time of diagosis LADA, some of them
- when patients upon failure of oral hypoglycemic
treatment.
Keywords: LADAdiabetes mellitusdiagnosistreatment