open access

Vol 9, No 6 (2008): Practical Diabetology
Original articles (submitted)
Published online: 2008-12-22
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The contribution of the selected parameters of lipid metabolism to the development of diabetic nephropathy in children and adolescents with diabetes mellitus type 1

Małgorzata Myśliwiec, Katarzyna Zorena, Anna Balcerska
Diabetologia Praktyczna 2008;9(6):241-245.

open access

Vol 9, No 6 (2008): Practical Diabetology
Original articles (submitted)
Published online: 2008-12-22

Abstract


BACKGROUND. The aim of the work was to evaluate lipid metabolism and its influence on the development of diabetic nephropathy in children and adolescents with diabetes mellitus type 1.
MATERIAL AND METHODS. 185 children with diabetes mellitus type 1 were enrolled in the study. The control group consisted of 86 healthy children. All the children had HbA1c, triglycerides, total cholesterol and its HDL and LDL fractions as well as daily urinary albumin secretion assessed.
RESULTS. No statistically significant differences were observed between children with diabetes mellitus type 1 and the healthy controls. When comparing children with diabetes mellitus type 1 presenting with microalbuminuria (group A) to patients with diabetes mellitus type 1 without overt microalbuminuria (group B) and healthy children it come out that the levels of total cholesterol and its LDL fraction were statistically significantly higher in group A with regard to the healthy children but were not significantly different between group B patients and the control group. Statistical analysis of the selected lipid parameters and HbA1c levels has shown a statistically significant increase in the level of total cholesterol (p < 0.001) its LDL fraction (p < 0.001) and triglycerides (p < 0.001) correspondingly to the duration of the disease.
CONCLUSIONS. Presence of the proper lipid profile during the first years of diabetes mellitus type 1 in children cannot guarantee that afterward the patient will not demonstrate clinical symptoms of the diabetic nephropathy.

Abstract


BACKGROUND. The aim of the work was to evaluate lipid metabolism and its influence on the development of diabetic nephropathy in children and adolescents with diabetes mellitus type 1.
MATERIAL AND METHODS. 185 children with diabetes mellitus type 1 were enrolled in the study. The control group consisted of 86 healthy children. All the children had HbA1c, triglycerides, total cholesterol and its HDL and LDL fractions as well as daily urinary albumin secretion assessed.
RESULTS. No statistically significant differences were observed between children with diabetes mellitus type 1 and the healthy controls. When comparing children with diabetes mellitus type 1 presenting with microalbuminuria (group A) to patients with diabetes mellitus type 1 without overt microalbuminuria (group B) and healthy children it come out that the levels of total cholesterol and its LDL fraction were statistically significantly higher in group A with regard to the healthy children but were not significantly different between group B patients and the control group. Statistical analysis of the selected lipid parameters and HbA1c levels has shown a statistically significant increase in the level of total cholesterol (p < 0.001) its LDL fraction (p < 0.001) and triglycerides (p < 0.001) correspondingly to the duration of the disease.
CONCLUSIONS. Presence of the proper lipid profile during the first years of diabetes mellitus type 1 in children cannot guarantee that afterward the patient will not demonstrate clinical symptoms of the diabetic nephropathy.
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Keywords

diabetes mellitus type 1; children; lipid profiles; nephropathy diabetica

About this article
Title

The contribution of the selected parameters of lipid metabolism to the development of diabetic nephropathy in children and adolescents with diabetes mellitus type 1

Journal

Clinical Diabetology

Issue

Vol 9, No 6 (2008): Practical Diabetology

Pages

241-245

Published online

2008-12-22

Bibliographic record

Diabetologia Praktyczna 2008;9(6):241-245.

Keywords

diabetes mellitus type 1
children
lipid profiles
nephropathy diabetica

Authors

Małgorzata Myśliwiec
Katarzyna Zorena
Anna Balcerska

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