Vol 9, No 6 (2008): Practical Diabetology
Review article
Submitted: 2012-01-02
Published online: 2008-12-22
Drug-induced hypoglycemia in type 2 diabetic patients
Roman Kuczerowski
Diabetologia Praktyczna 2008;9(6):277-284.
Vol 9, No 6 (2008): Practical Diabetology
Review articles (submitted)
Submitted: 2012-01-02
Published online: 2008-12-22
Abstract
Drug-induced hypoglycemia is one of the most relevant
limiting factors in obtaining good metabolic
control necessary to prevent angiopathy in diabetic
patients. Mortality associated with insulin therapy
is estimated as 2-4%. Hypoglycemic coma is a life-threatening state. Prolonged hypoglycemia may cause
irreversible neurological deficiencies. Hypoglycemia
may induce cardiac ischemia and arrhythmias.
The risk factors of severe hypoglycemia include intensive
insulin therapy, old age, autonomic neuropathy,
impair secretion of counterregulatory hormones,
renal failure, liver injury and previous episode
of severe hypoglycemia. Hypoglycemia may be side
effect of treatment with insulin, sulfonylureas, glinides,
DPP-4 inhibitors. Metformin in monotherapy
does not cause hypoglycemia. Combined therapy (insulin
and metformin) may reduce the risk of hypoglycemia.
Education of patients and their families,
availability of self-control, appropriate management
of type 2 diabetes makes possible to obtain good
metabolic control without severe hypoglycemia.
Abstract
Drug-induced hypoglycemia is one of the most relevant
limiting factors in obtaining good metabolic
control necessary to prevent angiopathy in diabetic
patients. Mortality associated with insulin therapy
is estimated as 2-4%. Hypoglycemic coma is a life-threatening state. Prolonged hypoglycemia may cause
irreversible neurological deficiencies. Hypoglycemia
may induce cardiac ischemia and arrhythmias.
The risk factors of severe hypoglycemia include intensive
insulin therapy, old age, autonomic neuropathy,
impair secretion of counterregulatory hormones,
renal failure, liver injury and previous episode
of severe hypoglycemia. Hypoglycemia may be side
effect of treatment with insulin, sulfonylureas, glinides,
DPP-4 inhibitors. Metformin in monotherapy
does not cause hypoglycemia. Combined therapy (insulin
and metformin) may reduce the risk of hypoglycemia.
Education of patients and their families,
availability of self-control, appropriate management
of type 2 diabetes makes possible to obtain good
metabolic control without severe hypoglycemia.
Keywords
hypoglycemia; type 2 diabetes; pharmacotherapy
Title
Drug-induced hypoglycemia in type 2 diabetic patients
Journal
Clinical Diabetology
Issue
Vol 9, No 6 (2008): Practical Diabetology
Article type
Review article
Pages
277-284
Published online
2008-12-22
Page views
1065
Article views/downloads
6111
Bibliographic record
Diabetologia Praktyczna 2008;9(6):277-284.
Keywords
hypoglycemia
type 2 diabetes
pharmacotherapy
Authors
Roman Kuczerowski
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