Vol 9, No 6 (2008): Practical Diabetology
Review article
Published online: 2008-12-22

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Is insulin treatment always associated with weight gain? Insulin detemir in the light of clinical studies

Maciej T. Małecki, Jan Skupień
Diabetologia Praktyczna 2008;9(6):259-264.


In this review we describe the problem of excessive weight gain during insulin treatment in type 1 and type 2 diabetes. We explain possible causes of this phenomenon, such as hypoglycemia and defensive snacking, anabolic action of insulin, and results of non-physiologic mode of insulin administration. We explain advantages of use of detemir, a long-acting insulin analog, in patients with diabetes and illustrate mechanisms of its beneficial action in respect to weight gain.

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