Vol 10, No 2 (2009): Practical Diabetology
Research paper
Published online: 2009-06-25
Factors influencing occurrence and duration of partial remission in patients with type 1 diabetes
Diabetologia Praktyczna 2009;10(2):49-57.
Abstract
INTRODUCTION. The aim of this study was to analyze
parameters influencing on occurrence and duration
of remission in patients with type 1 diabetes.
MATERIAL AND METHODS. 136 patients with newly diagnosed type 1 diabetes were qualified to the prospective study. Metabolic control parameters and several data collected on the basis of questionnaires were taken into analyze.
RESULTS. Three months after hospitalization 98 subjects achieved partial remission. 35 patients had a duration of remission above 2 years, 24 patients between one year and two, and 39 subjects below one year. When compared with patients who didn’t experience remission remittents showed lower: fasting plasma glucose, postprandial plasma glucose, glycaemia on 3 a.m., serum triglyceride and higher HDL-cholesterol levels. Total daily insulin requirement at discharge from hospital was significantly lower in remission group. Using logistic regression significant association between insulin requirement level of triglyceride and occurrence of remission was found. According to the analysis of questionnaires group with remission characterized bigger founds to treatment, less stressful live, more seldom drinking coffee and smoking. In patients with duration of remission above 2 years we observed: shorter duration of diabetes before introduction of education and intensive functional insulin therapy, in comparison with subjects with duration below 1 year.
CONCLUSIONS. Metabolic disturbances prior to diagnosis, as well as style of life determine occurrence of remission phase in patients with type 1 diabetes. The faster the diagnosis of type 1 diabetes is made and the earlier the intensive functional insulin therapy is introduced the longer the duration of partial remission is.
MATERIAL AND METHODS. 136 patients with newly diagnosed type 1 diabetes were qualified to the prospective study. Metabolic control parameters and several data collected on the basis of questionnaires were taken into analyze.
RESULTS. Three months after hospitalization 98 subjects achieved partial remission. 35 patients had a duration of remission above 2 years, 24 patients between one year and two, and 39 subjects below one year. When compared with patients who didn’t experience remission remittents showed lower: fasting plasma glucose, postprandial plasma glucose, glycaemia on 3 a.m., serum triglyceride and higher HDL-cholesterol levels. Total daily insulin requirement at discharge from hospital was significantly lower in remission group. Using logistic regression significant association between insulin requirement level of triglyceride and occurrence of remission was found. According to the analysis of questionnaires group with remission characterized bigger founds to treatment, less stressful live, more seldom drinking coffee and smoking. In patients with duration of remission above 2 years we observed: shorter duration of diabetes before introduction of education and intensive functional insulin therapy, in comparison with subjects with duration below 1 year.
CONCLUSIONS. Metabolic disturbances prior to diagnosis, as well as style of life determine occurrence of remission phase in patients with type 1 diabetes. The faster the diagnosis of type 1 diabetes is made and the earlier the intensive functional insulin therapy is introduced the longer the duration of partial remission is.
Keywords: diabetes mellitus type 1remissionlifestyleintensive insulin therapy