Vol 10, No 4 (2009): Practical Diabetology
Review article
Published online: 2009-11-05
Cellular therapy in diabetes type 1 - will it be possible?
Diabetologia Praktyczna 2009;10(4):157-161.
Abstract
Type 1 diabetes is results from the irreversible
damage of the pancreatic beta cells which leads to
disturbance and even to total termination of insulin
production. Despite enormous progress in the
treatment of type 1 diabetes still most of the patients
develop late diabetic complications. Because of that,
type 1 diabetes is one of targets of the cellular
therapy. Nowadays, in vitro culture of differentiated
beta cells continues to be at the scientific research
level. However several studies indicate that in the
future it would be possible to culture pancreatic
insulin-producing beta cells which would be sensitive
to glucose level in blood and which would be possible
to be injected to type 1 diabetic patients with. Success
of such treatment will depend however on many
factors, including safe protocols to culture beta cells.
Additionally, it would also be important to make sure
that immunological response against cells will not
appear and that such cells will maintain their biological
features.
Keywords: type 1 diabetesstem cellscellular therapy