Pathogenetic relationship between diabetic micro- and macroangiopathy Part I. Microangiopathy: an update

Abstract

Current opinions concerning pathogenesis of diabetic microangiopathy are presented. The special attention was concentrated on hyperglycemia-induced biochemical disturbances as well as on the inflammatory cells participation in microcirculation derangement. Using the known pathogenic mechansisms responsible for diabetic microangiopathy, the optimal procedures aiming at prevention of cardiovascular complications are suggested.