Vol 10, No 6 (2009): Practical Diabetology
Review article
Published online: 2010-05-11
Rationale for starting insulin therapy in type 2 diabetes patients with once-daily Levemir®. Background of the SOLVE study in combination therapy
Diabetologia Praktyczna 2009;10(6):217-222.
Abstract
The primary goal of the management of diabetes
mellitus is the attainment of normoglycaemia, or
near normoglycaemia. The importance of such achievements
in reducing or delaying the occurrence of
the micro and macro vascular complications of diabetes
was clearly illustrated in the Diabetes Control
and Complications Study (DCCT) and in the United
Kingdom Prospective Diabetes Study (UKPDS). Treatment
of Type 2 diabetes has during recent years
moved from secondary (or specialist physician) to
primary (or general practitioner/family physician) care
thus increasing the number of physicians and patients
initiating insulin therapy in combination with
oral antidiabetics drugs (OADs). With such diversified
use, there is a need to complement the data
from randomized controlled trials supporting such recommendation with data from large observational
studies in real-life setting. Such studies sub serve
the primary objective of monitoring safety of such
newly-approved use in real-life setting in a large
population. SOLVE study aims to document the safety
of Levemir® when used once-daily in combination
with OADs in type 2 diabetes in a real-life setting.
In current review we also discuss need of early
initiating insulin therapy in patients with type 2 diabetes
and why once daily insulin detemir is a good
choice for that.
Keywords: diabetes mellitus type 2basal insulinsinsulin detemirSOLVE