open access

Vol 11, No 5 (2010): Practical Diabetology
Original articles (submitted)
Published online: 2011-02-16
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Vildagliptin use in a triple oral therapy in patients not effectively treated with two oral antihyperglycemic agents

Mariusz Dąbrowski
Diabetologia Praktyczna 2010;11(5):153-159.

open access

Vol 11, No 5 (2010): Practical Diabetology
Original articles (submitted)
Published online: 2011-02-16

Abstract

INTRODUCTION. The aim of this study was to assess the efficacy and safety of vildagliptin in subjects not achieving satisfactory glycemic control while on two oral antihyperglycemic agents, and not agreeing to begin insulin therapy.
MATERIAL AND METHODS. 21 patients, among them 6 women, aged between 46 and 90 years (mean 63.5 ± 10.4 years), suffering from type 2 diabetes from one year up to 22 years (mean 10.6 ± 5.6 years), treated with vildagliptin from 4 up to 22.5 months (mean 12.5 ± 6.0 months) were observed. Impact of vildagliptin treatment on metabolic control, weight, blood pressure value and hypoglycemia frequency was evaluated.
RESULTS. After vildagliptin was added to the therapy with two oral hypoglycemic drugs, HbA1c level decreased significantly by 0.7% from 8.19 ± 0.77% at baseline to 7.49 ± 0.96% at the end of the study (p = 0.002). This improvement was maintained all along the observation. During vildagliptin treatment patient’s weight remained unchanged, diastolic blood pressure significantly decreased from 84.2 ± 9.8 mm Hg to 80.5 ± 7.5 mm Hg (p = 0.014), and trend towards systolic blood pressure reduction from 150.3 ± 23.0 mm Hg to 145.3 ± 17.0 mm Hg was also observed (p = 0.136). No patient experienced severe hypoglycemia episode, and also frequency of mild hypoglycemia didn’t increase.
CONCLUSIONS. Vildagliptin, despite lack of an official registration for use in the subjects with type 2 diabetes treated with two oral hypoglycemic drugs, appeared to be effective and safe alternative method of therapy intensification in a group of patients not achieving good glycemic control on such a treatment. (Diabet. Prakt. 2010; 11, 4: 153–159)

Abstract

INTRODUCTION. The aim of this study was to assess the efficacy and safety of vildagliptin in subjects not achieving satisfactory glycemic control while on two oral antihyperglycemic agents, and not agreeing to begin insulin therapy.
MATERIAL AND METHODS. 21 patients, among them 6 women, aged between 46 and 90 years (mean 63.5 ± 10.4 years), suffering from type 2 diabetes from one year up to 22 years (mean 10.6 ± 5.6 years), treated with vildagliptin from 4 up to 22.5 months (mean 12.5 ± 6.0 months) were observed. Impact of vildagliptin treatment on metabolic control, weight, blood pressure value and hypoglycemia frequency was evaluated.
RESULTS. After vildagliptin was added to the therapy with two oral hypoglycemic drugs, HbA1c level decreased significantly by 0.7% from 8.19 ± 0.77% at baseline to 7.49 ± 0.96% at the end of the study (p = 0.002). This improvement was maintained all along the observation. During vildagliptin treatment patient’s weight remained unchanged, diastolic blood pressure significantly decreased from 84.2 ± 9.8 mm Hg to 80.5 ± 7.5 mm Hg (p = 0.014), and trend towards systolic blood pressure reduction from 150.3 ± 23.0 mm Hg to 145.3 ± 17.0 mm Hg was also observed (p = 0.136). No patient experienced severe hypoglycemia episode, and also frequency of mild hypoglycemia didn’t increase.
CONCLUSIONS. Vildagliptin, despite lack of an official registration for use in the subjects with type 2 diabetes treated with two oral hypoglycemic drugs, appeared to be effective and safe alternative method of therapy intensification in a group of patients not achieving good glycemic control on such a treatment. (Diabet. Prakt. 2010; 11, 4: 153–159)
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Keywords

vildagliptin; type 2 diabetes; glycated hemoglobin; weight; blood pressure

About this article
Title

Vildagliptin use in a triple oral therapy in patients not effectively treated with two oral antihyperglycemic agents

Journal

Clinical Diabetology

Issue

Vol 11, No 5 (2010): Practical Diabetology

Pages

153-159

Published online

2011-02-16

Bibliographic record

Diabetologia Praktyczna 2010;11(5):153-159.

Keywords

vildagliptin
type 2 diabetes
glycated hemoglobin
weight
blood pressure

Authors

Mariusz Dąbrowski

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