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Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies
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Abstract
MATERIAL AND METHODS. Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies.
RESULTS. Data were available for 5 cohort and 25 casecontrol studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2–9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I2 = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates.
CONCLUSIONS. There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age. (Diabet. Prakt. 2010; 11, 5: 181–193)
Abstract
MATERIAL AND METHODS. Relevant studies published before June 2009 were identified from MEDLINE, Web of Science, and EMBASE. Authors of studies were contacted and asked to provide individual patient data or conduct prespecified analyses. Risk estimates of type 1 diabetes by maternal age were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were used to derive combined odds ratios and to investigate heterogeneity among studies.
RESULTS. Data were available for 5 cohort and 25 casecontrol studies, including 14,724 cases of type 1 diabetes. Overall, there was, on average, a 5% (95% CI 2–9) increase in childhood type 1 diabetes odds per 5-year increase in maternal age (P = 0.006), but there was heterogeneity among studies (heterogeneity I2 = 70%). In studies with a low risk of bias, there was a more marked increase in diabetes odds of 10% per 5-year increase in maternal age. Adjustments for potential confounders little altered these estimates.
CONCLUSIONS. There was evidence of a weak but significant linear increase in the risk of childhood type 1 diabetes across the range of maternal ages, but the magnitude of association varied between studies. A very small percentage of the increase in the incidence of childhood type 1 diabetes in recent years could be explained by increases in maternal age. (Diabet. Prakt. 2010; 11, 5: 181–193)
About this articleTitle
Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies
Journal
Issue
Vol 11, No 5 (2010): Practical Diabetology
Article type
Other materials agreed with the Editors
Pages
181-193
Published online
2011-02-16
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575
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1570
Bibliographic record
Diabetologia Praktyczna 2010;11(5):181-193.
Authors
Chris R. Cardwell
Lars C. Stene
Geir Joner
Max K. Bulsara
Ondrej Cinek
Joachim Rosenbauer
Johnny Ludvigsson
Mireia Jané
Jannet Svensson
Michael J. Goldacre
Thomas Waldhoer
Przemysława Jarosz-Chobot
Suely G.A. Gimeno
Lee-Ming Chuang
Roger C. Parslow
Emma J.K. Wadsworth
Amanda Chetwynd
Paolo Pozzilli
Girts Brigis
Brone Urbonaite
Sandra Šipetić
Edith Schober
Gabriele Devoti
Constantin Ionescu-Tirgoviste
Carine E. de Beaufort
Denk