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Vol 11, No 5 (2010): Practical Diabetology
Review article
Submitted: 2012-01-02
Published online: 2011-02-16
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Role of metabolic disorders and coexisting inflammatory process in etiopatogenesis of vascular endothelial dysfunction in patients with type 2 diabetes

Katarzyna Wasilewska, Halina Kemona
Diabetologia Praktyczna 2010;11(5):173-180.

open access

Vol 11, No 5 (2010): Practical Diabetology
Review articles (submitted)
Submitted: 2012-01-02
Published online: 2011-02-16

Abstract

There is a dramatic increase in the number and seriousness of casus of type 2 diabetes in the world. It often has an asymptomatic onset, at the moment of diagnosis around 50% of patients already suffer from organs complications. Long lasting hyperglycemia causes damage vessels. Albuminuria is a marker of general damage to the vascular endothelial. Metabolic disorders have influence to confirms albuminuria by way of a effect of “glucotoxicity”, as and coexisting inflammatory process. Inhibition excessive activation VEGF, NF-kB, as well as estimate CRP and IL-6 concentration in the blood in type 2 diabetes patients may in contribute to the development of modern therapeutic methods, which can lead to the reduction of the risk of chronic complications as the prevalence and mortality rate of cardio-vascular disorders in this patients. (Diabet. Prakt. 2010; 11, 5: 173–180)

Abstract

There is a dramatic increase in the number and seriousness of casus of type 2 diabetes in the world. It often has an asymptomatic onset, at the moment of diagnosis around 50% of patients already suffer from organs complications. Long lasting hyperglycemia causes damage vessels. Albuminuria is a marker of general damage to the vascular endothelial. Metabolic disorders have influence to confirms albuminuria by way of a effect of “glucotoxicity”, as and coexisting inflammatory process. Inhibition excessive activation VEGF, NF-kB, as well as estimate CRP and IL-6 concentration in the blood in type 2 diabetes patients may in contribute to the development of modern therapeutic methods, which can lead to the reduction of the risk of chronic complications as the prevalence and mortality rate of cardio-vascular disorders in this patients. (Diabet. Prakt. 2010; 11, 5: 173–180)

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Keywords

type 2 diabetes; hyperglycemia; inflammatory process; VEGF; NF-kB; IL-6; CRP

About this article
Title

Role of metabolic disorders and coexisting inflammatory process in etiopatogenesis of vascular endothelial dysfunction in patients with type 2 diabetes

Journal

Clinical Diabetology

Issue

Vol 11, No 5 (2010): Practical Diabetology

Article type

Review article

Pages

173-180

Published online

2011-02-16

Page views

671

Article views/downloads

3952

Bibliographic record

Diabetologia Praktyczna 2010;11(5):173-180.

Keywords

type 2 diabetes
hyperglycemia
inflammatory process
VEGF
NF-kB
IL-6
CRP

Authors

Katarzyna Wasilewska
Halina Kemona

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