open access

Vol 9, No 5 (2020)
Research paper
Published online: 2020-09-23
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Maternal circulating status of vitamin D, adiponectin and lipid ratios in gestational diabetes mellitus

Ali Khosrowbeygi, Hassan Ahmadvand
DOI: 10.5603/DK.2020.0038
·
Clinical Diabetology 2020;9(5):321-327.

open access

Vol 9, No 5 (2020)
ORIGINAL ARTICLES
Published online: 2020-09-23

Abstract

Background. The present research was an attempt to assess maternal serum values of 25-hydroxy vitamin D3 [25(OH)D3], adiponectin and the lipid ratios and comparison of their associations with insulin resistance and insulin sensitivity in gestational diabetes mellitus (GDM). Methods. It was conducted on 100 participants including 49 women with GDM and 51 normal pregnant women at 24–28 weeks of gestation. Maternal fasting serum values of glucose, 25(OH)D3, lipid profile, adiponectin and insulin were assessed and the lipid ratios and biomarkers of resistance and sensitivity to insulin were calculated. Statistical significance was set at P < 0.05. Results. Current research revealed that levels of 25(OH) D3 were significantly lower in GDM than in normal pregnancy. Binary logistic regression analysis showed that GDM was associated negatively with 25(OH)D3, HDL-C and adiponectin and positively with the lipid ratios. Multiple linear regression analysis showed that only values of 25(OH)D3 were independently associated negatively with the insulin resistance (P = 0.012). Conclusions. Levels of 25(OH)D3 were significantly decreased in GDM compared with normal pregnancy. On the other hand, 25(OH)D3 had a significant negative correlation with insulin resistance which was stronger than the lipid ratios and adiponectin.

Abstract

Background. The present research was an attempt to assess maternal serum values of 25-hydroxy vitamin D3 [25(OH)D3], adiponectin and the lipid ratios and comparison of their associations with insulin resistance and insulin sensitivity in gestational diabetes mellitus (GDM). Methods. It was conducted on 100 participants including 49 women with GDM and 51 normal pregnant women at 24–28 weeks of gestation. Maternal fasting serum values of glucose, 25(OH)D3, lipid profile, adiponectin and insulin were assessed and the lipid ratios and biomarkers of resistance and sensitivity to insulin were calculated. Statistical significance was set at P < 0.05. Results. Current research revealed that levels of 25(OH) D3 were significantly lower in GDM than in normal pregnancy. Binary logistic regression analysis showed that GDM was associated negatively with 25(OH)D3, HDL-C and adiponectin and positively with the lipid ratios. Multiple linear regression analysis showed that only values of 25(OH)D3 were independently associated negatively with the insulin resistance (P = 0.012). Conclusions. Levels of 25(OH)D3 were significantly decreased in GDM compared with normal pregnancy. On the other hand, 25(OH)D3 had a significant negative correlation with insulin resistance which was stronger than the lipid ratios and adiponectin.

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Keywords

vitamin D, gestational diabetes, adiponectin, insulin resistance

About this article
Title

Maternal circulating status of vitamin D, adiponectin and lipid ratios in gestational diabetes mellitus

Journal

Clinical Diabetology

Issue

Vol 9, No 5 (2020)

Article type

Research paper

Pages

321-327

Published online

2020-09-23

DOI

10.5603/DK.2020.0038

Bibliographic record

Clinical Diabetology 2020;9(5):321-327.

Keywords

vitamin D
gestational diabetes
adiponectin
insulin resistance

Authors

Ali Khosrowbeygi
Hassan Ahmadvand

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