open access

Vol 7, No 3 (2018)
REVIEW ARTICLES
Published online: 2018-05-21
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The importance of epigenetic factors for the diagnostics and treatment of type 2 diabetes mellitus

Agnieszka Stelmaszyk, Marzena Dworacka
DOI: 10.5603/DK.2018.0013
·
Clinical Diabetology 2018;7(3):164-170.

open access

Vol 7, No 3 (2018)
REVIEW ARTICLES
Published online: 2018-05-21

Abstract

The level of expression of certain genes modifying the phenotype may affect the progression of diabetes mellitus and its complications. Gene expression is controlled by epigenetic modifications, influenced by intracellular and environmental factors, e.g. nutrition model and physical activity. These modifications appear throughout whole life, from conception until the time of death, and they are closely dependent on cell differentiation, DNA repair and cellular stress. Hopefully, the knowledge of epigenetics might be used in the future as an element of personalized treatment of diabetes. The following article aims to review the most important mechanisms of epigenetic modifications in context of pathogenesis and pathophysiology of type 2 diabetes mellitus.

Abstract

The level of expression of certain genes modifying the phenotype may affect the progression of diabetes mellitus and its complications. Gene expression is controlled by epigenetic modifications, influenced by intracellular and environmental factors, e.g. nutrition model and physical activity. These modifications appear throughout whole life, from conception until the time of death, and they are closely dependent on cell differentiation, DNA repair and cellular stress. Hopefully, the knowledge of epigenetics might be used in the future as an element of personalized treatment of diabetes. The following article aims to review the most important mechanisms of epigenetic modifications in context of pathogenesis and pathophysiology of type 2 diabetes mellitus.

Get Citation

Keywords

epigenetics; type 2 diabetes mellitus; metabolic memory; intergenerational transmission

About this article
Title

The importance of epigenetic factors for the diagnostics and treatment of type 2 diabetes mellitus

Journal

Clinical Diabetology

Issue

Vol 7, No 3 (2018)

Pages

164-170

Published online

2018-05-21

DOI

10.5603/DK.2018.0013

Bibliographic record

Clinical Diabetology 2018;7(3):164-170.

Keywords

epigenetics
type 2 diabetes mellitus
metabolic memory
intergenerational transmission

Authors

Agnieszka Stelmaszyk
Marzena Dworacka

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