open access

Vol 3, No 3 (2014)
Case reports
Published online: 2014-07-10
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DPP-4 inhibitor as add-on therapy in uncontrolled type 2 diabetes treated with multiple insulin injections

Mariusz Dąbrowski
Diabetologia Kliniczna 2014;3(3):125-130.

open access

Vol 3, No 3 (2014)
Case reports
Published online: 2014-07-10

Abstract

Type 2 diabetes is a progressive disease and stepwise intensification of therapy is required to maintain good metabolic control. In the clinical practice recommendations of scientific societies intensive insulin therapy with multiple daily injections is the final stage of the treatment. In everyday clinical practice, however, we often encounter a situation where, despite such treatment, satisfactory glycemic control is not achieved. In this situation the question arises: whether the only therapeutic option is to systematically increase the dose of insulin? New anti-diabetic agents make it possible to find other solutions. The purpose of this paper is to present cases of patients in whom, instead of increasing the dose of insulin, a dipeptidyl peptidase-4 (DPP-4) inhibitor was added to the treatment. The observation lasting ≥ 6 months confirmed efficacy and safety of this strategy.

Abstract

Type 2 diabetes is a progressive disease and stepwise intensification of therapy is required to maintain good metabolic control. In the clinical practice recommendations of scientific societies intensive insulin therapy with multiple daily injections is the final stage of the treatment. In everyday clinical practice, however, we often encounter a situation where, despite such treatment, satisfactory glycemic control is not achieved. In this situation the question arises: whether the only therapeutic option is to systematically increase the dose of insulin? New anti-diabetic agents make it possible to find other solutions. The purpose of this paper is to present cases of patients in whom, instead of increasing the dose of insulin, a dipeptidyl peptidase-4 (DPP-4) inhibitor was added to the treatment. The observation lasting ≥ 6 months confirmed efficacy and safety of this strategy.
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Keywords

type 2 diabetes, intensive insulin therapy, DPP-4 inhibitor, vildagliptin

About this article
Title

DPP-4 inhibitor as add-on therapy in uncontrolled type 2 diabetes treated with multiple insulin injections

Journal

Clinical Diabetology

Issue

Vol 3, No 3 (2014)

Pages

125-130

Published online

2014-07-10

Bibliographic record

Diabetologia Kliniczna 2014;3(3):125-130.

Keywords

type 2 diabetes
intensive insulin therapy
DPP-4 inhibitor
vildagliptin

Authors

Mariusz Dąbrowski

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