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The use of low doses of long-acting insulin as an effective therapy in latent autoimmune diabetes in adults — cases report
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Abstract
Latent autoimmune diabetes in adults (LADA) is an autoimmune disorder due to the presence of anti-islet antibodies with slow progression to complete beta-cell secretory insufficiency. Clinical trials proved that the insulin treated patients with LADA maintain better beta-cell function. However the optimal insulin therapy has not been established. We report three clinical cases of LADA. The treatment in those cases have been based on small doses (< 0.15 IU/kg) long-acting insulin injections once daily for 3 to 6 years with good metabolic and clinical control. It might be a good alternative for optimal management in LADA patients which maintains long clinical remission as a manifestation of beta-cell protection, but further studies exploring the best treatment in patients with LADA are needed.
Abstract
Latent autoimmune diabetes in adults (LADA) is an autoimmune disorder due to the presence of anti-islet antibodies with slow progression to complete beta-cell secretory insufficiency. Clinical trials proved that the insulin treated patients with LADA maintain better beta-cell function. However the optimal insulin therapy has not been established. We report three clinical cases of LADA. The treatment in those cases have been based on small doses (< 0.15 IU/kg) long-acting insulin injections once daily for 3 to 6 years with good metabolic and clinical control. It might be a good alternative for optimal management in LADA patients which maintains long clinical remission as a manifestation of beta-cell protection, but further studies exploring the best treatment in patients with LADA are needed.
Keywords
latent autoimmune diabetes in adults, treatment with low doses of long-acting insulin
About this articleTitle
The use of low doses of long-acting insulin as an effective therapy in latent autoimmune diabetes in adults — cases report
Journal
Issue
Article type
Case report
Pages
79-83
Published online
2014-05-14
Page views
681
Article views/downloads
3280
Bibliographic record
Diabetologia Kliniczna 2014;3(2):79-83.
Keywords
latent autoimmune diabetes in adults
treatment with low doses of long-acting insulin
Authors
Olga Jachimowicz-Duda
Katarzyna Zorena
Małgorzata Myśliwiec