open access

Vol 3, No 2 (2014)
Case reports
Published online: 2014-05-14
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The use of low doses of long-acting insulin as an effective therapy in latent autoimmune diabetes in adults — cases report

Olga Jachimowicz-Duda, Katarzyna Zorena, Małgorzata Myśliwiec
Diabetologia Kliniczna 2014;3(2):79-83.

open access

Vol 3, No 2 (2014)
Case reports
Published online: 2014-05-14

Abstract

Latent autoimmune diabetes in adults (LADA) is an autoimmune disorder due to the presence of anti­-islet antibodies with slow progression to complete beta-cell secretory insufficiency. Clinical trials proved that the insulin treated patients with LADA maintain better beta-cell function. However the optimal insulin therapy has not been established. We report three clinical cases of LADA. The treatment in those cases have been based on small doses (< 0.15 IU/kg) long­-acting insulin injections once daily for 3 to 6 years with good metabolic and clinical control. It might be a good alternative for optimal management in LADA patients which maintains long clinical remission as a manifestation of beta-cell protection, but further studies exploring the best treatment in patients with LADA are needed.

Abstract

Latent autoimmune diabetes in adults (LADA) is an autoimmune disorder due to the presence of anti­-islet antibodies with slow progression to complete beta-cell secretory insufficiency. Clinical trials proved that the insulin treated patients with LADA maintain better beta-cell function. However the optimal insulin therapy has not been established. We report three clinical cases of LADA. The treatment in those cases have been based on small doses (< 0.15 IU/kg) long­-acting insulin injections once daily for 3 to 6 years with good metabolic and clinical control. It might be a good alternative for optimal management in LADA patients which maintains long clinical remission as a manifestation of beta-cell protection, but further studies exploring the best treatment in patients with LADA are needed.

Get Citation

Keywords

latent autoimmune diabetes in adults, treatment with low doses of long-acting insulin

About this article
Title

The use of low doses of long-acting insulin as an effective therapy in latent autoimmune diabetes in adults — cases report

Journal

Clinical Diabetology

Issue

Vol 3, No 2 (2014)

Pages

79-83

Published online

2014-05-14

Bibliographic record

Diabetologia Kliniczna 2014;3(2):79-83.

Keywords

latent autoimmune diabetes in adults
treatment with low doses of long-acting insulin

Authors

Olga Jachimowicz-Duda
Katarzyna Zorena
Małgorzata Myśliwiec

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