Skin dysfunction in diabetes. Part 1 — function of skin cells

Abstract

Skin is one of the largest organs in the body. It is composed of epidermis, dermis and subcutaneous tissue. Skin changes in diabetes are similar to accelerated aging process. This paper presents the changes in the skin cells functions in the presence of hyperglycemia. We also describe the mechanisms of assessment of glycation of skin proteins, and the impact of the formation of advanced glycation end products on the properties of the skin. The variety of skin cells, glucose dependence, and their easy availability should make changes in the skin an equivalent of late diabetic complications.