open access

Vol 3, No 3 (2014)
Review articles (submitted)
Published online: 2014-07-10
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Skin dysfunction in diabetes. Part 1 — function of skin cells

Małgorzata Mackiewicz-Wysocka, Aleksandra Araszkiewicz, Bogna Wierusz-Wyscoka
Diabetologia Kliniczna 2014;3(3):108-116.

open access

Vol 3, No 3 (2014)
Review articles (submitted)
Published online: 2014-07-10

Abstract

Skin is one of the largest organs in the body. It is composed of epidermis, dermis and subcutaneous tissue. Skin changes in diabetes are similar to accelerated aging process. This paper presents the changes in the skin cells functions in the presence of hyperglycemia. We also describe the mechanisms of assessment of glycation of skin proteins, and the impact of the formation of advanced glycation end products on the properties of the skin. The variety of skin cells, glucose dependence, and their easy availability should make changes in the skin an equivalent of late diabetic complications.

Abstract

Skin is one of the largest organs in the body. It is composed of epidermis, dermis and subcutaneous tissue. Skin changes in diabetes are similar to accelerated aging process. This paper presents the changes in the skin cells functions in the presence of hyperglycemia. We also describe the mechanisms of assessment of glycation of skin proteins, and the impact of the formation of advanced glycation end products on the properties of the skin. The variety of skin cells, glucose dependence, and their easy availability should make changes in the skin an equivalent of late diabetic complications.

Get Citation

Keywords

diabetes, skin, skin cells function, inflammatory process

About this article
Title

Skin dysfunction in diabetes. Part 1 — function of skin cells

Journal

Clinical Diabetology

Issue

Vol 3, No 3 (2014)

Pages

108-116

Published online

2014-07-10

Bibliographic record

Diabetologia Kliniczna 2014;3(3):108-116.

Keywords

diabetes
skin
skin cells function
inflammatory process

Authors

Małgorzata Mackiewicz-Wysocka
Aleksandra Araszkiewicz
Bogna Wierusz-Wyscoka

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