open access

Vol 2, No 6 (2013)
Review
Published online: 2013-12-30
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The relationship between obesity and the risk of progression of chronic kidney disease in patients with type 2 diabetes and methods of treatment

Andrzej Brymora, Sławomir Badurek, Marek Muszytowski
Diabetologia Kliniczna 2013;2(6):226-235.

open access

Vol 2, No 6 (2013)
Review
Published online: 2013-12-30

Abstract

Diabetic nephropathy is one of the main and most important causes of end-stage renal disease. The increase in the incidence of diabetes correlates with worldwide epidemic of obesity, which, together with hypertension and other elements of the metabolic syndrome affects an increased risk of cardiovascular complications compounded by a progressive decline in glomerular filtration rate. Daily medical practice shows that clinical diagnosis of diabetic nephropathy is preceded by an increase in glomerular filtration rate, the presence of microalbuminuria and glomerular hypertrophy. Poor glycemic control, elevated blood pressure exacerbate proteinuria and renal injury up to an irreversible end-stage renal disease. A similar sequence of events occurs in obese, non-diabetic patients. Therefore, prevention and treatment of obesity in people with diabetes is a key element inhibiting progression of kidney disease and it is as important as striving to fulfill the criteria for compensation of carbohydrate metabolism. The paper presents the impact of obesity on the progression of chronic kidney disease in people with type 2 diabetes and methods of treatment: nonpharmacological, pharmacological and surgical.

Abstract

Diabetic nephropathy is one of the main and most important causes of end-stage renal disease. The increase in the incidence of diabetes correlates with worldwide epidemic of obesity, which, together with hypertension and other elements of the metabolic syndrome affects an increased risk of cardiovascular complications compounded by a progressive decline in glomerular filtration rate. Daily medical practice shows that clinical diagnosis of diabetic nephropathy is preceded by an increase in glomerular filtration rate, the presence of microalbuminuria and glomerular hypertrophy. Poor glycemic control, elevated blood pressure exacerbate proteinuria and renal injury up to an irreversible end-stage renal disease. A similar sequence of events occurs in obese, non-diabetic patients. Therefore, prevention and treatment of obesity in people with diabetes is a key element inhibiting progression of kidney disease and it is as important as striving to fulfill the criteria for compensation of carbohydrate metabolism. The paper presents the impact of obesity on the progression of chronic kidney disease in people with type 2 diabetes and methods of treatment: nonpharmacological, pharmacological and surgical.
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Keywords

type 2 diabetes, nephropathy, chronic kidney disease, obesity, risk factors

About this article
Title

The relationship between obesity and the risk of progression of chronic kidney disease in patients with type 2 diabetes and methods of treatment

Journal

Clinical Diabetology

Issue

Vol 2, No 6 (2013)

Pages

226-235

Published online

2013-12-30

Bibliographic record

Diabetologia Kliniczna 2013;2(6):226-235.

Keywords

type 2 diabetes
nephropathy
chronic kidney disease
obesity
risk factors

Authors

Andrzej Brymora
Sławomir Badurek
Marek Muszytowski

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