open access

Vol 2, No 4 (2013)
Review
Published online: 2013-09-03
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Prediabetes — time for non-pharmacologic and pharmacologic intervention

Leszek Czupryniak
Diabetologia Kliniczna 2013;2(4):144-149.

open access

Vol 2, No 4 (2013)
Review
Published online: 2013-09-03

Abstract

2.5 million individuals in Poland suffer from diabetes, including every fourth person aged > 60. The challenge is to diagnose type 2 diabetes early as at the beginning it causes very few significant clinical symptoms or signs. Type 2 diabetes is typically preceded by prediabetes, the term which encompasses impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). IFG subjects have 5-fold, and IGT 6-fold greater yearly risk of developing diabetes. Moreover, hyperglycemia is exerting its damaging effect on vasculature already at the stage of prediabetes as cardiovascular risk is raised by 70% in IGT and by 20% in IFG subjects. According tothe recommendations of Diabetes Poland subjects with prediabetes should be offered non-pharmacological treatment aiming at body weight loss through caloric restriction and increased physical activity as well as — more recently — pharmacotherapy with the use of metformin. Upon a set of clinical cases, the paper discusses therapeutic options for individuals with prediabetes.

Abstract

2.5 million individuals in Poland suffer from diabetes, including every fourth person aged > 60. The challenge is to diagnose type 2 diabetes early as at the beginning it causes very few significant clinical symptoms or signs. Type 2 diabetes is typically preceded by prediabetes, the term which encompasses impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). IFG subjects have 5-fold, and IGT 6-fold greater yearly risk of developing diabetes. Moreover, hyperglycemia is exerting its damaging effect on vasculature already at the stage of prediabetes as cardiovascular risk is raised by 70% in IGT and by 20% in IFG subjects. According tothe recommendations of Diabetes Poland subjects with prediabetes should be offered non-pharmacological treatment aiming at body weight loss through caloric restriction and increased physical activity as well as — more recently — pharmacotherapy with the use of metformin. Upon a set of clinical cases, the paper discusses therapeutic options for individuals with prediabetes.
Get Citation

Keywords

prediabetes, impaired fasting glucose, impaired glucose tolerance, diabetes prevention, metformin

About this article
Title

Prediabetes — time for non-pharmacologic and pharmacologic intervention

Journal

Clinical Diabetology

Issue

Vol 2, No 4 (2013)

Pages

144-149

Published online

2013-09-03

Bibliographic record

Diabetologia Kliniczna 2013;2(4):144-149.

Keywords

prediabetes
impaired fasting glucose
impaired glucose tolerance
diabetes prevention
metformin

Authors

Leszek Czupryniak

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