Vol 2, No 4 (2013)
Review article
Published online: 2013-09-03

open access

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The role of melatonin in type 2 diabetes mellitus

Melania Mikołajczyk
Diabetologia Kliniczna 2013;2(4):136-143.


A negative relationship between shift work and an increased risk of some chronic diseases has been reported. Available data has shown that biological circadian rhythm disruption plays an important role indeveloping impaired glucose tolerance and type 2 diabetes (T2DM). This review article concerns the impactof the biological clock, melatonin, clock gene mutations and single nucleotide polymorphisms melaton in receptor gene on glucose homeostasis in experimental and clinical studies.