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open access

Vol 2, No 4 (2013)
Review article
Submitted: 2013-09-03
Accepted: 2013-09-03
Published online: 2013-09-03
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The role of melatonin in type 2 diabetes mellitus

Melania Mikołajczyk
DOI: 10.5603/cd.35633
·
Diabetologia Kliniczna 2013;2(4):136-143.

open access

Vol 2, No 4 (2013)
Review
Submitted: 2013-09-03
Accepted: 2013-09-03
Published online: 2013-09-03

Abstract

A negative relationship between shift work and an increased risk of some chronic diseases has been reported. Available data has shown that biological circadian rhythm disruption plays an important role indeveloping impaired glucose tolerance and type 2 diabetes (T2DM). This review article concerns the impactof the biological clock, melatonin, clock gene mutations and single nucleotide polymorphisms melaton in receptor gene on glucose homeostasis in experimental and clinical studies.

Abstract

A negative relationship between shift work and an increased risk of some chronic diseases has been reported. Available data has shown that biological circadian rhythm disruption plays an important role indeveloping impaired glucose tolerance and type 2 diabetes (T2DM). This review article concerns the impactof the biological clock, melatonin, clock gene mutations and single nucleotide polymorphisms melaton in receptor gene on glucose homeostasis in experimental and clinical studies.

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Keywords

type 2 diabetes mellitus, circadian rhythm, melatonin, melatonin receptors

About this article
Title

The role of melatonin in type 2 diabetes mellitus

Journal

Clinical Diabetology

Issue

Vol 2, No 4 (2013)

Article type

Review article

Pages

136-143

Published online

2013-09-03

Page views

649

Article views/downloads

8133

DOI

10.5603/cd.35633

Bibliographic record

Diabetologia Kliniczna 2013;2(4):136-143.

Keywords

type 2 diabetes mellitus
circadian rhythm
melatonin
melatonin receptors

Authors

Melania Mikołajczyk

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