Reversibility of diabetic nephropathy

Abstract

Currently, diabetic nephropathy is the major cause ofend-stage renal disease and renal replacement therapy. Chronic hyperglycemia leads to functional and morphologic abnormalities and subsequent decline of kidney function. That is associated with increased morbidity and mortality. Early diagnosis of diabetic nephropathy allows to initiate treatment which can invert or inhibit progression of diabetic nephropathy. In this review we present methods that may lead to a reversion of functional and morphologic abnormalities in the course of diabetic nephropathy in patients with type 1 and type 2 diabetes.